cytotoxic

cytotoxic

1. 3.Enhanced cytotoxic activity of cytotoxic T cells and NK cells.

3. 加强毒T细胞和NK细胞的细胞毒素活性。

2. Although 99% of trials with cytotoxic agents determined an MTD, only 64% of trials with targeted agents did.

99%的细胞毒性药物相关的临床试验会确立最大耐受剂量，而仅有64%靶向药物相关的临床试验会确立最大耐受剂量。

3. Cytotoxic rates of group B to SMMC7721 cells, MCF-7 cells and PC-3 cells were 23.37%、27.55% and 24.84% respectively.

B组效应细胞对人SMMC-7721细胞、MCF-7、PC-3细胞细胞的杀伤率分别为23.37%、27.55%、24.84%。

4. It plays a key role in the pathogenesis of HN that cytotoxic CD8+ T cells eliminate central nevus.

CD8+为主的T细胞清除痣细胞是发病机制中的关键环节。

5. CIK cells can down regulate the expression of P glycoprotein in MCF7 adr cell line remarkably, and synergistic cytotoxic effect against MCF7 adr cell line can be detected when combined with ADR.

CIK细胞可明显抑制MCF7adr肿瘤细胞系的P gp表达 ,可协同阿霉素提高对MCF7adr肿瘤细胞系的杀伤活性。

6. cytotoxic lymphocyte maturation factor

CLMF

7. The cytotoxic rates of the effector cells on the target cells in group of mice immunized with BCG,pTB30s and the control group of mice with injection of saline were 28.14%,45.18% and 5.13% respectively.

CTL杀伤实验:BCG、pTB30s及NS对照组杀伤率分别为28.14%、45.18%和5.13%。

8. The in vitro and in vivo levels of mIL-12 and the in vivo activity of cytotoxic T lymphocyte(CTL)were examined by ELISA assay and modified LDH release assay,respectively.

ELISA法检测细胞上清及小鼠血液中mIL-12水平,LDH释放法检测小鼠体内细胞毒性T淋巴细胞(CTL)杀伤活性。

9. Keywords K562 cell;dendritic cell;exosome;cytotoxic T lymphocyte;

K562细胞;树突状细胞;外泌体;细胞毒T淋巴细胞;

10. All LEM-GM-CSF, LEM and DHAQ had cytotoxicity on HL60/ADM, their cytotoxic power in decrement sequence: LEM-GM-CSF, LEM, DHAQ.

LEM-GM-CSF、LEM及DHAQ对HL60/ADM细胞具有杀伤作用,且LEM-GM-CSF的杀伤作用显著强于LEM和DHAQ。

11. monocyte-derived cytotoxic factor

MDCF

12. The proliferation of cytotoxic T lymphocyte(CTL)cocultured in the mHSPs+Cy+IL-12 group was significantly remarkable and the content of CD8+ CTLs was significantly more in comparison with the other groups(P<0.01).

mHSPS免疫组和mHSPs+Cy+IL-12免疫组体外诱生的CTL反应活性均比对照组的CTL活性有所升高,尤其mH-SPs+Cy+IL-12免疫组升高明显,且随效靶比的上升而上升;

13. MTr test showed that curcumin was cytotoxic to cells.

MTT结果表明姜黄素对LoVo细胞具有细胞毒作用。

14. Results of the MTT assay showed that GBS exhibits a significant cytotoxic effect in HL-60 cells, and we found that the cytotoxic effect is a result of apoptosis as evidenced by morphological change, DNA fragmentation, and flow cytometry.

MTT还原测定(单核细胞直接细胞毒性测定)结果显示GBS对HL-60细胞有明显的细胞毒作用,通过形态学改变、DNA断裂及流式细胞计量术,我们发现其细胞毒作用是凋亡的结果。

15. Cytotoxic T Lymphocyte Response Against SARS-CoV

SARS冠状病毒特异性细胞毒T淋巴细胞免疫应答的研究

16. STT exerts its cytotoxic effect on BEL-7402 cells by inducing apoptosis.

STT在体外能抑制BEL 74 0 2细胞的增殖并能诱导细胞凋亡 ,其诱导凋亡作用的途径之一是下调Bcl 2蛋白表达。

17. cytotoxic T lymphocyte- associated antigen 4

T淋巴细胞毒性相关抗原4

18. second cytotoxic T-cell factor

T细胞再次杀伤因子

19. Pang JX,Ma RQ,Liu LM,et al.Total alkaloid of Macleaya cordata:in vitro cytotoxic effect on Hep3B cells and in vivo antitumor effect in mice[J].J South Med Univ,2005,25(3):325-8.

[5]庞建新,马仁强,刘兰梅,等.博落回总碱对肝癌细胞的毒性作用和体内抗肿瘤作用[J].南方医科大学学报,2005,25(3):325-8.

20. antireticular cytotoxic sera

[医] 抗网状细胞毒血清

21. Nitric oxide as a cytotoxic factor may be partial to kill sperm and the sperm suppression activity due to infertility.

一氧化氮作为局部细胞毒因子可杀灭精子和抑制精子的活动力而致不孕。

22. Barriers to efficacy of standard cytotoxic agents are related to drug-delivery challenges and inherent chemoresistance.

不幸的是，在现实中，化疗并没有取得实质性的成功。

23. To further inestigate the role of capsaicin on the immune system, the authors challenged mice with a colon cancer cell line, which has a well-defined cytotoxic T-cell (CTL) epitope.

为了研究辣椒素在免疫系统中的作用，研究人员在一种结肠癌细胞系种植小鼠上实验，该细胞系具有明显细胞毒性T细胞(CTL)抗原决定簇。

24. Cytotoxic T lymphocyte (CTL) responses、activated by HLA antigen presentation、are implicated in the control of HIV replication.

人类白血球抗原激发的T淋巴细胞与HIV病毒的复制有关连。

25. With adjuvant of CpG or the cell wall skeleton of coryne bacterium parvum ( CB Pw) , we analyzed each groups T-cell proliferation and cytotoxic T lymphocyte ( CTL) response.

以CpG基序作为佐剂,以CBPw作为对照佐剂,测定各组的T细胞增殖试验和CTL活性。

26. Liquid cell culture and conventional chromosome assay were used to evaluate the cytotoxic effect of IFN,HHT and Ara c on CML Ph + cell.

以药物作用 2 4小时液体培养及常规染色体分析法研究 IFN、HHT及 Ara- c对 10例 CML 慢性期患者的骨髓中 Ph+ 细胞的生长影响。

27. But NIAID pulled the plug on its trial after an examination of the data from a phase II study showed that fewer than 30 percent of the volunteers generated cytotoxic T cells against HIV.

但是NIAID在审视了该疫苗第二阶段试验的数据，发现只有不到30%的受试者体内产生对抗HIV的杀手细胞，于是他们决定终止试验。

28. It has been shown, in vitro, to be effective in eliciting a cytotoxic T-cell response to prostate cancer.

体外研究证明，该先导肽可造成针对前列腺癌的免疫细胞毒T细胞反应。

29. The cytotoxic assay showed that the conjugate had a selective killing to human hepatic cancer cell line BEL_(7404), which 41. 2% BEL_(7404) cell was killed at a concentration of 10~(-9)mol/L,the conjugate was no toxic to. SL_7.

体外细胞毒结果表明:结合物对靶细胞具有良好的导向杀伤作用,在10~(-9)mol/L浓度时对人肝癌细胞株BEL7404的杀伤率为41.2%,对正常细胞SL_7的杀伤力很弱。

30. As a cytotoxic chemical, an important mode for TBT effects on the cells is to induce apoptosis.

作为一种细胞毒性化学物,诱发细胞凋亡是TBT作用于细胞的一种重要方式。

31. cytotoxic T(thymus dependent)lymphocyte line

依赖胸腺性细胞毒性T淋巴细胞系

32. Immune effector cells, cytotoxic effector molecules and cytokine producing cells were quantified after immunohistochemical staining in lobular and portal areas of the biopsies.

免疫效应细胞，细胞毒效应分子和细胞因子产生细胞在活检的肝小叶和门脉区行免疫组织化学染色后行定量分析。

33. Keywords Dendritic cell;cytotoxic T lymphocyte;gastric cancer;biotherapy;

关键词树突状细胞;细胞毒性淋巴细胞;胃癌;生物治疗;

34. Keywords umbilical cord blood;CD3AK;cytotoxic activity;

关键词脐血;CD3AK细胞;杀伤活性;

35. Keywords Phenethylbiguanide Islet A cells Cytotoxic effect Morphometry Rat;

关键词降糖灵;胰岛A细胞;毒性作用;形态计量学;大鼠;

36. Compounds 1 and 2 are new compounds,some compounds showed cytotoxic activities on SF-268,MCF-7 and HepG2 cell lines.

其中化合物1和2为新化合物,部分化合物显示一定的细胞毒活性。

37. One of the most important actions of T cells is to lyse the cells expressing specific antigens. Most cells with such cytotoxic activity are CD8~+ T cells called cytotoxic T lymphocytes (CTLs).

具有这种细胞毒性作用的T细胞的表面抗原大部分是CD_8阳性，被称为细胞毒性T淋巴细胞(cytotoxic T lymphocytes，CTLs)。

38. V. vulnificus strains produce an extracellular cytotoxin (cytolysin) that is known to be cytotoxic to a variety of cells, including the erythrocyte, by disrupting the cell membrane.

创伤弧菌会分泌一种藉由破坏细胞膜而对许多细胞及红血球具有毒性的细胞溶解毒素，此毒素也会造成血管通透性增加以及小鼠死亡。

39. The former are brought about by T lymphocytes termed cytotoxic T cells, that seek out and kill virally-infected host cells or cancer cells.

前者是由称之为毒T细胞的T淋巴球，去搜寻并杀灭受到感染的细胞或癌细胞。

40. Mabs antitumour activity is mediated through direct interaction with specific target molecules, deployment of immune cytotoxic pathways, or through chaperoning cytotoxic agents to tumour.

单克隆抗体的抗肿瘤活性是通过直接和特定的靶分子相互作用，免疫细胞毒素途径的部署，或者通过对肿瘤的陪伴性细胞毒素剂等进行调节的。

41. monocyte-derived cytotoxic factor(MDCF)

单核细胞来源的细胞毒性因子

42. The bispecific antibody could induce P BLs to cytotoxic test of colonic cells in vivo.

双功能抗体能够介导PBLs对CL187细胞的杀伤作用。

43. In addition, only certain murine mAb isotypes hae been shown to effectiely bind to and actiate elements of the human immune system, thereby triggering cytotoxic effector functions10.

另外，只有某些亚型的鼠单抗可以有效的结合并激活人免疫系统，以激发细胞毒作用[10]。

44. HSV - tk/ACV system showed strong cytotoxic effect, which suggested to has a strong bystander effect in vivo.

在体内HSV-tk/ACV系统具有强的细胞毒作用,提示存在着强的旁观者效应。

45. However, cytotoxic T lymphocytes might function through perforin pathway only.

在扁平苔藓中，细胞毒性T淋巴细胞的作用方式可能仅为穿孔素途径。

46. At this stage a large amount of peripheral blood of HIV, the immune system of HIV by producing antibodies and cytotoxic lymphocytes to virus resistance.

在这个阶段外周血中产生大量的艾滋病病毒，免疫系统通过产生艾滋病病毒抗体和细胞毒淋巴细胞来抵抗病毒。

47. Lichen metabolites exert a wide variety of biological actions including antibiotic, antimycobacterial, antiviral, antiinflammatory, analgesic, antipyretic, antiproliferative and cytotoxic effects.

地衣代谢物用于一系列各种各样的生物学行为包括抗生素、抗细菌、抗病毒、抗炎、止痛、除虫、抗增殖和细胞毒性效应等。

48. Keywords oxaliplatin analog;characterization;cytotoxic activity;

奥沙利铂类似物;表征;细胞毒性;

49. XF can help cytotoxic lymphocytes (CTL), NK cells and macrophages to clear virus through regulating the activities of Th1 cytokines.

宣肺透解剂可能通过调节Th1型细胞因子的活性而增强细胞毒T细胞(CTL细胞)、自然杀伤细胞(NK细胞)和巨噬细胞对病毒的清除。

50. The fouling organisms from Qingdao were collected to study the antineoplastic activity, the crude extracts of 18 species of marine fouling organisms were assayed by brine shrimp cytotoxic method.

对青岛沿海海洋附着生物资源进行调查,采用海虾细胞毒性法及流式细胞术对已鉴定的18种附着生物进行抗肿瘤活性筛选。

51. Although Taxol showed good cytotoxic activity to tumor cells growing in tissue culture and in several rodent tumor systems, its interest waned for nearly a decade for two reasons.

尽管紫杉醇对在组织培养中的恶性肿瘤和几种恶性肿瘤细胞系实验中显示了极强的细胞毒性，但在被发现之后的近十年来并未能引起人们的足够广泛的重视。

52. Clinical studies suggest a potential role for BLyS in the progress of lymphoid malignancies.Chimeric toxin is a heterogeneous molecule that is composed of homing molecule and cytotoxic molecule.

嵌合毒素是具有导向能力的分子（载体）和具有细胞毒性的分子（毒素）偶联而成的具有特异性细胞杀伤能力的杂合分子。

53. Cytotoxic Influence of Pentoxifylline on Pyrimidine Antagonist

己酮可可碱对嘧啶拮抗物细胞毒性的影响

54. The dynamic relationship between cytotoxic effect and incubated time with TPT was investigated by flow cytometry and immunological analysis.

应用新的流体细胞测量仪(FACS-Vantage)及免疫分析法对细胞培养时间、TPT的浓度与拓扑酶中毒程度的动力学关系进行了研究。

55. Trillet-lenoir V.; Green J.; Manegold C. et al. Recombinant granulocyte colony-stimulating factor reduces the infectious complications of cytotoxic chemotherapy 1993; 29A(3):319.

张述,刘叙仪,方健等.重组人粒细胞集落刺激因子预防肺癌化疗期感染的效果中华结核和呼吸杂志1998;21(6):355.

56. The cells when exposed to cytotoxic agents, the apoptosis lead to cell death.

当细胞暴露在毒素剂下时，凋亡导致细胞死亡。

57. The mechanism by which chronic-phase CML cells become resistant to conventional cytotoxic drugs, such as hydroxyurea, is unknown.

慢性期CML细胞对常规细胞毒药物，如羟基脲产生抗药性的机理还不清楚。

58. fibroblast-derived tumor cytotoxic factor

成纤维细胞衍化肿瘤细胞毒因子

59. antibody-dependent cytotoxic cell

抗体依赖性细胞毒性淋巴细胞

60. Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs.

抗体偶联药物能提高抗体的抗肿瘤能力并减少有效细胞毒性药物的系统性副作用。

61. The binding of antigenic peptide sequences to major histocompatibility complex（MHC） molecules is a prerequisite for stimulation of cytotoxic T cell responses.

抗原多肽序列与主要组织相容性复合体(MHC)分子的结合是引起T细胞免疫应答的先决条件。

62. antireticuloendothelial cytotoxic serum

抗网状内皮细胞毒性血清

63. antireticular cytotoxic serum

抗网状内皮细胞毒血清

64. Anti-tumor cytotoxic T lymphocytes

抗肿瘤CTL

65. According to their function can be divided into three subgroups: T helper cells, inhibition of cytotoxic T cells and T cells.

按其功能可分为三个亚群：辅助性T细胞、抑制性T细胞和细胞毒性T细胞。

66. Abstract: Pyrrolizidine alkaloids(PAs) are widely distributed in plantae.Many PAs are hepatotoxic,Lung toxicity(carcinogenesis),neurotoxic and cytotoxic.

摘 要： 吡咯里西啶生物碱广泛分布于植物界。

67. Abstract Objective To study the cytotoxic effect of thiotepa (THT) and mitomycin C (MMC) on human bladder cancer cell line in vitro.

摘要 目的 探讨体外膀胱灌注噻替哌和丝裂霉素C药物浓度和作用时间对膀胱癌细胞杀伤作用的影响。

68. Although the cytotoxic effects of mercuric chloride (HgCl2) and methylmercury chloride (MeHg) have been extensively studied, the insoluble HgS was subjected fewer studies.

摘要:汞是目前环境中污染较严重的重金属之一，它以元素汞、无机汞及有机汞三种型式在环境中循环。

69. Most anticancer drugs are cytotoxic, and healthcare workers may be exposed to these drugs via drug extravasation, volatilization, and while providing patient care.

摘要化学治疗药物具有细胞毒性，医院工作人员在药物处理流泻、照护病人、处理废弃物过程中，可能因为药物外渗、挥发、飞沫、或接触病患排泄物而造成职业暴露。

70. Objective To detect the expression and distribution of activated cytotoxic cells in types of lymphoma with tissue microarray, and provide evidences for clinical treatment and prognosis.

摘要目的运用组织芯片及常规技术检测活化的细胞毒性细胞在各型淋巴瘤中的表达分布情况，为临床治疗和判断预后提供依据。

71. Abstract: Aim To observe the effects of B7.1 gene expression on proliferation of hepatocarcinoma cells and on changes in cytotoxic activity of induced CTL.

摘要： 目的观察B7.1基因表达对肝癌细胞增殖特性的影响及诱发杀伤性T淋巴细胞(CTL)细胞毒活性的变化。

72. In vitro cytotoxic study of a new dentin bonding agents

新型牙本质黏结剂体外细胞毒性研究

73. Another study showed that stimulating the specific cytotoxic lymphocytes maybe the efficient way for chronic hepatitis to clear the virus and gain recovery.

新近研究认识到，通过刺激特异性CTL应答可能是促进慢乙肝患者病毒清除和机体恢复的一种有效途径。

74. METHODS The cytotoxic effects of 5-FU on AsPC-1, Capan-1, Mia-PaCa-2, Panc-1 and T3M4 pancreatic cancer cells were assessed by the sulforhodamine B protein assay (SRB).

方法 用 SRB方法检测5 - FU对胰腺癌细胞株 As PC- 1、Capan- 1、Mia- Pa Ca- 2、Panc- 1和 T3 M4的毒性作用。

75. Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.

显示细胞生长抑制和细胞毒活性。EGFR激酶抑制剂。有抗血管生成活性。

76. The cytotoxic and cytogenetic effect of sodium arsenite and sodium arsenate on Chinese hamster ovary (CHO) cells is reported.

本文报告了亚砷酸钠和砷酸钠对中国地鼠卵巢细胞(CHO)的毒性和细胞遗传学效应。

77. Anti-T-cells, in science CD8 cytotoxic T lymphocytes is called, is the main objective of the new study of AIDS.

杀伤性T细胞，在科学上称为CD8细胞毒性T淋巴细胞，是目前艾滋病新研究的主要目标。

78. Dendritic cells (DCs) are the most potent antigen presenting cells (APCs) that prime naive T lymphocytes and active antigen specific cytotoxic T lymphocytes(CTLs), which makes DC a promising tools for immunotherapy of cancer .

树突状细胞(Dendritic Cells,DCs)作为功能最强的抗原提呈细胞，在恶性肿瘤的免疫治疗中起着重要的作用。

79. CYTOTOXIC EFFECT OF ACANTHAMOEBA TROPHOZOITE ON MOUSE MELANOMA

棘阿米巴对黑色素瘤细胞毒性作用初探

80. CYTOTOXIC EFFECT OF ACANTHAMOEBA TROPHOZOITES ON HUMAN MELANOMA CELLS

棘阿米巴滋养体致黑色素瘤细胞损伤的初步研究