hirudin
hirudin
1. (2) The density of PDGF hi vitreous cavity of high and low dosage treatment groups of hirudin was markedly lower than that of model group (P<0.05);
(2)水蛭素高、低剂量治疗组玻璃体腔内PDGF浓度明显低于模型对照组(P＜0.01)。
2. Directed Evolution of Hirudin by DNA shuffling
DNA改组技术在水蛭素实验进化中的应用
3. Unique formula: Blood-cleaing Potent Reducer contains hirudin, an acid polypeptide which is effective in anti-coagulation and anti-thrombosis.
“血清王”的酸性多肽--水蛭素，具有抗凝、抗血栓等作用。
4. Keywords human parathyroid hormone （hPTH）;clone;expression;Reteplase;12 peptides of hirudin;Thrombolysis;Antieoagulation;
人甲状旁腺激素;克隆;基因表达;瑞替普酶;水蛭素12肽;溶栓;抗凝;
5. Construction and Expression of a Fusion Protein Made of Tissue-type Plasminogen Activator and Hirudin in Pichia pastoris
人组织型纤溶酶原激活剂-水蛭素融合基因的构建及其在毕赤酵母中的表达
6. The content of hypoxanthine in Hirudo was measured by high performance liquid chromatography(HPLC)and Hirudin was determined by thrombin.
以凝血酶法测定水蛭素的含量;以HPLC测定次黄嘌呤的含量。
7. As a direct thrombin inhibitor, recombinant hirudin(r-hirudin) has played an important role in clinical use.
作为直接凝血酶抑制剂,重组水蛭素在临床上的应用已越来越重要。
8. Keywords disseminated intravascular coagulation;lipopolysaccharides;hirudin;rabbits;r ecombinant hirudin;
关键词弥散性血管内凝血;脂多糖类;水蛭素;兔;重组水蛭素;
9. Keywords hirudin;isolation;purification;assay;
关键词水蛭素;分离;纯化;检测;
10. Keywords hirudin;Pichia pastoris;gene recombination;
关键词水蛭素;毕赤酵母;基因重组;
11. Keywords hirudin;polyethylene glycols;chemical modific ation;half-life;
关键词水蛭素;聚乙二醇;化学修饰;半衰期;
12. Keywords recombinant hirudin;Pichia pastoris;glycerol;
关键词重组水蛭素;毕赤酵母;甘油;
13. Keywords Recombinant hirudin;Capacitive immunosensors;Thioctic acid （TA）;Mercaptoacetic acid （MAA）;Self-assembled monolayers （SAMs）;Regeneration;
关键词重组水蛭素;电容型免疫传感器;巯辛酸;巯基乙酸;自组装单层膜;再生;
14. Keywords thrombin;astrocyte;hypoxia/reoxygenation;hirudin;
凝血酶;星形胶质细胞;缺氧/复氧;水蛭素;
15. Keywords thrombin;hirudin;intercellular adhesive molecules;
凝血酶;水蛭素;细胞黏附分子;
16. Keywords Saccharomyces cerevisiae;Hirudin;Purification;Decolourization;
啤酒酵母;重组水蛭素;纯化;脱色;
17. Construction of phage-displayed library by DNA shuffling and the screening of potent hirudin variants
噬菌体改组库的构建及高活性水蛭素变异体的筛选
18. Compound hirudin
复方水蛭素
19. Keywords Compound hirudin;W256 tumor;Superoxide dismutase;Lipid peroxidation;
复方水蛭素;W256肿瘤;超氧化物歧化酶;脂质过氧化物;
20. Changes of brain water content after intracerebral hemorrhage and the inhibitory effect of hirudin on cerebral edema in rats
大鼠脑出血后脑含水量的变化及水蛭素的干预作用
21. Isolation and Purification of Hirudin from the Leeches
天然水蛭素的提取和纯化
22. If they have had adequate time for the clopidogrel to soak in and work， then I like the hirudin analogue approach.
如果患者有足够的时间供氯吡格雷吸收起效，那么我选择水蛭素类似物。
23. Keywords Experimental intracerebral hemorrhage;Apoptosis;Hirudin;
实验性脑出血;凋亡;水蛭素;
24. dog brain blood flow was increased and peripheral resistance was reduced after injecting hirudin.
家犬用药后血流量明显增加 ( P<0 .0 1 )、外周阻力下降 ( P<0 .0 1 )。
25. The preventive effect of local application of hirudin on expanded flap venous congestion
局部应用水蛭素对扩张皮瓣静脉淤血的防治
26. X-ray photoelectron spectroscopy (XPS) proved that hirudin molecules were effectively immobilized on PET films.
改性表面的水接触角降低，亲水性得到改善。
27. Design and Functional Investigation of a Novel Anti-coagulative Fusion Protein by Hirudin With a Recognizing Sequence of FXa
新型水蛭素嵌合抗栓剂的构建表达与功能研究
28. This paper introduces their mechanism,function and clinical research, illustrates their advantages compated with heparin, believing that both hirudin and hirulog are new promising antithrombotic agents.
本文介绍了他们的作用机理及其临床研究，叙述了他们与肝素相比的优越之外，认为水蛭素与水蛭肽是两类非常有前途的抗栓新药。
29. Employing recombinant DNA technique, it’s constructed by introducing the Arg-Gly-Asp (RGD) sequence to the proper site of wild-type hirudin.
样品是通过重组DNA技术将精氨酸-甘氨酸-天冬氨酸 (RGD)序列融合在野生水蛭素的合理部位，经过表达和纯化后得到的高纯度重组水蛭素蛋白质。
30. Emerging Order of Species of Hirudin in Recombinant Pichia pastoris Fermentation
毕赤酵母发酵生产中的水蛭素降解顺序
31. Technical Improvements in Genetic Manipulation of Pichia pastoris and Their Application in Hirudin Expression
毕赤酵母基因操作技术的改进及其在水蛭素表达中的应用
32. Keywords leech;hirudin;hirulog;protein engineering;
水蛭;水蛭素;抗栓肽;蛋白质工程;
33. Keywords Hirudo;processing drug;extracts;hirudin;hypoxanthine;comparison of contents;
水蛭;炮制;浸出物;水蛭素;次黄嘌呤;含量比较;
34. recommant hirudin (r-hir)
水蛭素
35. hirudin and reteplase fusion protein
水蛭素12肽与瑞替普酶融合蛋白
36. Keywords Hirudin;Thrombin;Cerebral hemorrhage;Brain edema;
水蛭素;凝血酶;脑出血;脑水肿;
37. Keywords hirudin;recombinant hirudin （rH）;antithrombotic effect;thrombin time （TT）;prothrombin time （PT）;activated partial thromboplastin time （APTT）;
水蛭素;基因重组水蛭素;抗凝;凝血酶时间;凝血酶原时间;活化的部分凝血活酶时间;
38. Keywords hirudin;hirulog;thrombin;anticoagulant;
水蛭素;水蛭肽;凝血酶;抗栓剂;
39. Keywords hirudin;fibrinogen;thrombin;determination of activity;
水蛭素;纤维蛋白原;凝血酶;活性测定;
40. Keywords Hirudin;Lumbrukinase;Deep Venous Thromboses;Fracture of Hip;
水蛭素;蚓激酶;深静脉血栓;髋部骨折;
41. Keywords hirudin;recombinant hirudin;biological half-life;anticoagulant activity;activated partial thromboplastin time（APTT）;
水蛭素;重组水蛭素;生物半衰期;抗凝活性;APTT;
42. The Effective Study of Clotting Function with Hirudin and Aspirin in Patients with Cerebral Infarction
水蛭素和阿司匹林合用对脑梗死患者凝血功能影响的研究
43. Keywords hirudin gene;gene amplification;sequence analysis;Hirudinaria manillensis;
水蛭素基因;基因扩增;序列分析;菲牛蛭;
44. Establishment of DNA Family Shuffling Method for Hirudin Genes
水蛭素基因DNA家族改组方法的建立
45. Effect of Hirudin on Insulin Antibody of Type-2 Diabetes
水蛭素对2型糖尿病胰岛素抵抗的影响
46. Effects of hirudin for the thrombin-induced expression of adhesive molecules in neutrophils and human umbilical vein endothelial cells
水蛭素对凝血酶诱导血管内皮细胞与中性粒细胞表达黏附分子的影响
47. Inhibiting Effect of Hirudin on Thrombase-Induced Monolayer Permeability Increase in Vascular Endothelial Cells
水蛭素对凝血酶造成的血管内皮细胞单层通透性增高的抑制作用
48. Analytical Methods in Study Hirudin Activity
水蛭素活性分析方法的研究
49. hirudin peptide pharmaceutical raw material powder;
水蛭素肽粉医药原料；
50. Hirudin injection
水蛭肽
51. Keywords hVEGF_（165）;hirudin;fusion gene;gene expression;vector;
水蛭肽;基因融合;基因表达;载体;
52. The effect of hirudin injection on the brain blood flow of dog and brain edema of in mice
水蛭肽对犬脑血流量及大鼠缺血性脑水肿的影响
53. Effect of Hirudin Injection on Cerebral Ischemia in Rats and Brain Blood Flow in Dogs
水蛭肽注射液抗大鼠脑缺血作用及对犬脑血流量的影响
54. The recombinant plasmid was transformed into the yeast strain S. cerevisiae BJ1990 to carry out the primary expression experiment. In culture supernant of screened positive clone, the hirudin activity was detected to be 30 ATU/ml.
用正确的重组表达质粒转入酿酒酵母BJ1990细胞进行了初步表达实验，在筛选出的阳性克隆的培养上清中检测出的水蛭素活性为30ATU/ml，表达量达4mg/L。
55. Objective: To examine the effect of hirudin injection on cerebral ischemia and hemorheology of rat and the influence of brain blood flow in dog.
目的 :观察水蛭肽注射液对大鼠脑缺血、血液流变学及家犬脑血流量的影响。
56. Objective To investigate the effect of hirudin on brain edema and brain injuries after intracerebral hemorrhage.
目的探讨水蛭素对脑出血后脑水肿与脑组织损伤的影响。
57. AIM:To evaluate the effect of recombinant hirudin (r-hirudin) in reducing neointimal proliferation after balloon angioplasty in rabbits.
目的：探讨重组水蛭素对兔髂总动脉球囊损伤后内膜增殖的影响。
58. Results There are some relations between brain water and ion contents within the earlier time following intracerebral hemorrhage and hirudin reduces brain water and ion contents changes(P＜0.05).
结果大鼠脑出血后早期脑组织含水量、离子随时间推移而升高、变化，而水蛭素可减轻其水肿程度及离子变化(P＜0.05)。
59. Results The brain water in rabbit contusion and laceration brain was elevated as time went on, but hirudin reduced brain edema(P<0.05).
结果对照组家兔脑挫裂伤后脑组织含水量随时间的推移而升高,实验组各时间点脑组织含水量明显低于对照组(P<0.05)。
60. RESULTS:(1) The fundus and pathological slides showed that the hyperplasia memberane of the high and low dosage groups of hirudin was less than that of the model group;
结果：(1)眼底及常规病理切片显示，水蛭素高、低剂量治疗组增生情况较模型对照组程度轻。
61. The activity of hirudin was determined. RESULTS The activity of recombinant hirudin derivation in the culture medium reached 10 ATU/ml and a certain inhibitory effect on platelet condensation was also observed.
结果：细胞培液中，重组水蛭素衍生物的活性达到10ATU/ml，并有抗血小板凝集作用。
62. Conclusion Hirudin is able to inhibit the occurrence and development of traumatic brain edema;it can reduce complication and improve therapeutic effects if hirudin is used at the early stage.
结论水蛭素可抑制脑挫裂伤后脑水肿的发生和发展,早期应用水蛭素可减轻脑水肿,降低并发症,提高疗效。
63. CONCLUSIONS:Hirudin could prevent PVR from being formed or developing and had protective function on retina,whose mechanism related to the decrease of density of PDGF in vitreous body.
结论：水蛭素能抑制PVR的形成和发展，对视网膜有保护作用，其作用机制与减少玻璃体中血小板源性生长因子(PDGF)的浓度有关。
64. Isolation of PEGylated Hirudin and Analysis on It's Activity
聚乙二醇修饰水蛭素的分离纯化与活性分析
65. Immobilization of Recombinant Hirudin to Polyurethane Surfaces and Evaluation of Their Antithrombin Activity
聚氨酯表面偶联重组水蛭素及其抗凝血酶活性的评价
66. Keywords Maixuekang;capsules;cerebral hemorrhage;hirudin;
脉血康;胶囊;脑出血;水蛭素;
67. Keywords ICH;Thrombin;Hirudin;Brain injury;
脑出血;凝血酶;重组水蛭素;脑损伤;
68. Keywords Intracerebral hemorrhage;Plasminogen activator;Hirudin;Blood brin barrier;
脑出血;纤溶酶原激活剂;水蛭素;脑水肿;血脑屏障;
69. Keywords Intracerebral hemorrhage;Recombinant streptokinase;Hirudin;
脑出血;重组链激酶;水蛭素;
70. Keywords fusion protein;tissue-type plasminogen activator;hirudin;thrombolysis;anticoagulation;
融合蛋白;人组织型纤溶酶原激活剂;水蛭素;溶栓;抗凝;
71. Keywords fusion protein;thrombosis;anticoagulation;thrombolysis;staphylokinase;hirudin;
融合蛋白;溶栓;抗凝;血栓;水蛙素;葡激酶;
72. Keywords Vascular endothelial growth factor（VEGF）;Hirudin;Angioplasty;Restenosis;Fusion gene;Antiplatelet;Antithrombin;Reendothelialization;Gene therapy;
血管内皮生长因子;水蛭素;血管成形术;再狭窄;融合基因;抗血小板;抗凝血酶;再内皮化;基因治疗;
73. The antithrombotic effect of recombinant bifunctional hirudin after reconstruction of carotid artery in rabbits
重组双功能水蛭素的抗凝防栓作用
74. r - hirudin (rH)
重组水蛭素
75. Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia without ST elevation: a randomised trial
重组水蛭素(来匹卢定)与肝素对非ST段抬高型急性心肌梗塞患者的死亡率,心肌梗塞、顽固性心绞痛及再血管化操作发生率的不同影响
76. Recombinant hirudin (lepirudin) for the improvement of thrombolysis with streptokinase in patients with acute myocardial infarction: Results of the HIT-4 trial
重组水蛭素(来匹卢定)对急性心肌梗塞患者链激酶溶栓的改善状况:HIT-4试验结果
77. Keywords recombinant hirudin（rH）;disseminated intravascular coagulation（DIC）;pharmacological studies;
重组水蛭素;弥散性血管内凝血;药效学;
78. Keywords Recombinant hirudin;Selenite cataract;Galactose cataract;Pirenoxine;Irritation;
重组水蛭素;硒性白内障;糖性白内障;白内停;刺激性;
79. Keywords recombinant hirudin;fibrin;thrombin-activatable fibrinolysis inhibitor;factor XIII;
重组水蛭素;纤维蛋白;凝血酶激活的纤溶抑制物;XIII因子;
80. Keywords recombinant hirudin;xenopus pulmonary membrane;transport;mechanism;pulmonary absorption;
重组水蛭素;蟾蜍肺泡膜;转运;机制;肺部吸收;
