methotrexate

methotrexate

1. Keywords G4.0 PAMAM;methotrexate;drng release;MTX complex;

0聚酰胺胺树状大分子;甲氨蝶呤;药物释放;甲氨蝶呤复合物;

2. A 66-year-old woman started treatment with leflunomide in addition to her previous methotrexate therapy.

1例66岁妇女在以前甲氨喋呤的基础上加用来氟米特治疗。

3. A 67-year-old man was switched from methotrexate therapy to leflunomide, at which time he had no rheumatoid nodules.

1例67岁男性的甲氨喋呤治疗改变为来氟米特治疗，那时他没有类风湿结节。

4. Twenty-six patients were randomized to 24 weeks of etanercept or methotrexate.

26个患者随机服用依那西普或甲氨喋呤24周。

5. Two RCT have shown that methotrexate improves skin score in early diffuse SSc.

2项RCT研究表明，甲氨蝶呤可改善早期弥漫型的皮肤评分，但对其他器官病变的益处尚未确定。

6. The nonsensitive rate on ADM,DDP,5-Fu,MMC,DTIC,VCR,methotrexate(MTX) in 34 patients were 41.18%,17.65%,47.06%,50.00%,76.47%,61.76% and 52.94%,respectively.

34例患者对ADM、DDP、5-Fu、MMC、DTIC、VCR和MTX的不敏感率分别为41.18%、17.65%、47.06%、50.00%、76.47%、61.76%和52.94%。

7. 5-fluorouracil and methotrexate

5-氟脲嘧啶和氨甲喋啶

8. Neither methotrexate nor leucovorin was used in control group. Serum ALT and Cr,protein content of the liver,intestinal mucosa ALP and GGT,villus length were detected at 72 h after methotrexate injection.

72h后检测血清ALT和肌酐(Cr)、肝组织蛋白水平、小肠黏膜酶活性及绒毛长度。

9. FDA approes methotrexate, an anti-metabolite deried from folic acid, and 6-mercaptopurine as anti-cancer drugs.

FDA批准叶酸衍化的抗代谢药甲氨蝶呤和6-巯基嘌呤作为抗癌药物.

10. Abstract:Objective To investigate the mechanism of methotrexate (MTX) on human keratinocyte in vitro,and to understand the therapeutical mechanism of MTX on psoriasis.

[摘要]目的 探讨甲氨蝶呤（MTX）对表皮角质形成细胞的作用及影响，进而了解MTX治疗银屑病的机理。

11. A Analysis of Two-kinds of Single-dose Methotrexate Intravenously for Treatment of Ectopic Pregnancy

两种不同剂量氨甲喋呤单次静脉滴注治疗异位妊娠分析

12. They compared etanercept with methotrexate, the most common anti-rheumatic drug.

他们将依那西普与最常用的抗类风湿药物甲氨喋呤进行比较。

13. Exploration of low-dose calcium folinate for delayed rescuing toxicity of high-dose methotrexate

低剂量四氢叶酸钙延迟解救氨甲喋呤不良反应初探

14. Study on DNA damage caused by low-dose methotrexate

低剂量甲氨蝶呤对DNA损伤的研究

15. DNA Damage Caused by low Dose Methotrexate and Protective Effect of Folinic acid

低剂量甲氨蝶呤对DNA的损伤及甲酰四氢叶酸对其保护作用

16. A67- year-old man was switched from methotrexate therapy to leflunomide, at which time he had no rheumatoid nodules.

例67岁男性的甲氨喋呤治疗改变为来氟米特治疗，那时他没有类风湿结节。

17. Study of the Interaction between Methotrexate and Bovine Serum Albumin by Spectrometry

光谱法研究甲氨喋呤与牛血清白蛋白的相互作用

18. hexamethylmelamine, cyclophosphamide, methotrexate,5-fluorouracil

六甲基三聚氰胺、环磷酰胺、氨甲喋呤钠、5-氟尿嘧啶

19. hexamethylmelamine, Adriamycin, methotrexate

六羟甲基三聚氰胺、阿霉素、氨甲喋呤

20. Keywords Arthritis;Rheumatoid;Leflunomide;Methotrexate;Treatment;

关节炎;类风湿;来氟米特;甲氨蝶呤;治疗;

21. Keywords capillary zone electrophoreses;detection;methotrexate;

关键词毛细管区带电泳;分离;甲氨蝶呤;

22. The treatment group was treated with Guizhishaoyaozhimu Decoction and the control group was given Fenbid and methotrexate.

分别观察治疗前后临床症状、体征以及理化检查结果的变化。

23. Stikac,AndersonL,Frederiksen M.Single dose methotrexate for the treatment of ectopic pregnancy, Northwestern Memorial Hospital three-year experience.Am J Obstet Gynecol,1996,174(6):1840.

刘伯宁,孙剑英,陶文琪,等.米非司酮配伍米索前列醇终止早孕1774例分析.中国实用妇产科杂志,1994,10(4):231.

24. Kool S,Van Etten FHPM, Kock HCLV. Histopathology of five tubes after treatment with methotrexate[J]. Ferti Steril,1992(57):341.

刘珠风,郎景和,黄荣丽,等.甲氨喋呤单次肌肉注射治疗异位妊娠[J].中华妇产科杂志,1996,31(8):490492.

25. Pharmacokinetics of single-dose intramuscular injection of Methotrexate for the treatment of ectopic pregnancy

单剂量肌肉注射甲氨喋呤治疗异位妊娠的药物动力学

26. Donnez J，Godin PA，Bassil S. Successful methotrexate of a viable pregnancy within a thin uterine scar(correspondence)[J].Br J Obstet Gynecol，1997，104(10):1216.

单莹，范光升，金力.剖宫产术后子宫瘢痕妊娠13例临床分析[J].中国实用妇科与产科杂志，2006，2（2）：131.

27. bleomycin, cyclophosphamide, methotrexate, and 5-fluorouracil

博莱霉素、环磷酰胺、氨甲喋呤、5-氟尿嘧啶

28. BCNU, methotrexate procarbazine

卡氮芥、氨甲喋呤、甲基苄肼

29. Selective bilateral uterine artery methotrexate infusion and embolization for cervical pregnancy: report of 11 cases

双侧子宫动脉氨甲喋呤灌注加栓塞治疗宫颈妊娠11例效果分析

30. Oral mucositis is one of the common and serious complications caused by high-dose methotrexate.

口腔黏膜炎是大剂量甲氨蝶呤化疗后常见而严重的并发症之一。

31. Seventy five patients received CMF:cyclophosphamide 600mg/m 2 iv on day 1,methotrexate 40mg/m 2 iv on day 1,and 5 fluorouracil 600mg/m 2 iv on day 1.Three therapeutic courses were given with an interval of 21 days.

另外 75例接受CMF方案 ,CTX 6 0 0mg/m静推第 1天 ,MTX 40mg/m静推第 1天 ,5 FU 6 0 0mg/m静滴第 1天 ,均应用三周期以上。

32. In addition, the researchers obsere that that there was a BMD decrease in RA patients treated with methotrexate alone.

另外，研究人员发现单独接受甲氨喋呤治疗的RA患者出现BMD下降。

33. Folate may interfere with the efficacy of methotrexate, and antioxidants may preent the cellular oxidatie damage to cancer cells that are required for efficacy of radiotherapy and chemotherapy.

叶酸可能干扰氨甲喋呤的疗效，抗氧化剂可能会阻断放化疗效果所必需的对癌细胞的细胞氧化损伤。

34. The pivotal study, SERENE1, investigated patients suffering from RA who had an inadequate response to methotrexate (MTX) therapy, a commonly used RA drug.

在这个名为SERENE1的关键性研究中，受试对象为那些对常规RA药物甲氨蝶呤（MTX）反应较差的RA患者。

35. high-dose methotrexate and leucovorin

大剂量氨甲喋呤和甲酰四氢叶酸

36. Pharmacokinetics of Large Dose Methotrexate in the Treatment of Child Patients With Acute Lymphocytic Leukemia

大剂量氨甲喋呤治疗儿童急性淋巴细胞白血病的药代动力学

37. Nursing Care of Acute Lymphatic Leukemia Treated by High-dose of Methotrexate

大剂量氨甲喋呤治疗急性淋巴细胞白血病病人的护理

38. Leucovorin rescue after continuing infusion of high dose methotrexate

大剂量氨甲蝶呤持续静脉滴注后四氢叶酸钙解救方案的研究

39. methotrexate, high-dose+leucovorin rescue

大剂量甲氨喋呤-叶醛酸钙解救

40. Clinical studies of high-dose methotrexate used in treating acute Lymphocytic leukemia in children

大剂量甲氨喋呤治疗儿童白血病临床研究

41. Keywords High-dose methotrexate;Chemotherapy;Adverse effect;Riboflavin laurate;

大剂量甲氨喋岭;化疗;毒副反应;长效核黄素;

42. Study of pharmacokinetics in cerebrospinal fluid during high dose methotrexate chemotherapy

大剂量甲氨蝶呤化疗的脑脊液药代动力学研究

43. Prevention and nursing care of high-dose methotrexate chemotherapy result in oral musositis.

大剂量甲氨蝶呤化疗致口腔黏膜炎的预防及护理。

44. Observation and Nursing Care for Patients in High-dose Methotrexate Treatment for Acute Lymphocytic Leukemia

大剂量甲氨蝶呤治疗急性淋巴细胞白血病的观察及护理

45. Erythematous rashes in skin and oral mucosal erosion due to high-dose methotrexate in 2 children

大剂量甲氨蝶呤致儿童皮肤红斑疹与口腔黏膜糜烂2例

46. Determination of methotrexate concentration in rats'plasma and cerebrospinal fluid and the application

大鼠血浆和脑脊液中甲氨蝶呤浓度测定及其应用

47. Acetylated dendrimers were conjugated to folic acid as a targeting agent and then coupled to either methotrexate or tritium and either fluorescein or 6-carboxytetramethylrhodamine.

将叶酸作为靶向物与乙酰化树枝状结晶共轭，再将其与氨甲喋呤（或氚）和氢化荧光素（或6-carboxytetramethylrhodamine）配对。

48. Although her dose of prednisone is relatively low, she is also receiving infliximab in addition to the methotrexate and therefore should be considered immunosuppressed.

尽管病人所服泼尼松的剂量相当低,但病人除了服用甲氨蝶呤外,还服用infliximab,因此要考虑病人有免疫抑制。

49. Ectopic pregnancy；Medicine therapy； Methotrexate；Mifepristone

异位妊娠；药物治疗；甲氨蝶呤；米非司酮

50. prednisone, methotrexate, Adriamycin, cyclophosphamide, etoposide(VP-16-213)

强的松, 氨甲喋呤, 阿霉素, 环磷酰胺, 鬼臼乙叉苷

51. Abatacept is used in combination with methotrexate, when other disease modifiying antirheumatic drugs (DMARDs, eg sulfasalazine, infliximab) have not been effective or are not tolerated.

当其他的抗风湿药（抗风湿药，乙二醇柳氮磺胺吡啶，英夫利昔单抗）无效或者难以忍受时，调节剂如阿巴西普和氨甲叶酸结合用于治疗

52. We describe the case of a patient with a psoriatic flare over 98% of his body, despite methotrexate therapy.

我们描述了一位经氨甲蝶呤治疗后全身98%的部位仍不时出现干癣的患者。

53. We enrolled 189 patients with active RAdespite methotrexate therapy in a 3-month, multicenter,ascending-dose, double-blind, placebo-controlled trial.

我们登记了189个经3个月多中心、上行-剂量、双盲、安慰剂对照、甲氨蝶呤治疗的处于活动期RA患者。

54. This was paired in all groups with 10-25 mg doses each week of methotrexate, an arthritis drug that has shown to be stable before the study at these concentrations.

所有患者同时都接受10-25毫克/周的氨甲喋呤治疗，在这个研究之前使用该浓度的氨甲喋呤对病情稳定。

55. ALL maintenance therapy utilizes low-dose 6-mercaptopurine (6MP) and methotrexate (MTX), while maintenance in APL primarily consists of all-trans-retinoic acid (ATRA).

所有的维持疗法都使用低剂量的6-巯基嘌呤（6MP）和甲氨蝶呤（MTX），在APL初期的维持治疗中还要联合使用全反式维甲酸（ATRA）。

56. Lumpectomy followed by 6 courses of CMF (cyclophosphamide, methotrexate, fluorouracil).

手术后行6个疗程CMF（环磷酰胺，甲氨喋呤，氟尿嘧啶）的辅助化疗。

57. Maternal teratogens that hae been reported in association with cleft lip and palate include alcohol, maternal phenylketonuria, hyperthermia, hydantoin, trimethadione, aminopterin, and methotrexate.

据报道与唇腭裂相关的母体的致畸因素有酒精、母体的苯丙酮尿症、高热、乙内酰脲、三甲双酮、氨喋呤、氨甲蝶呤等。

58. Abstract ABSTRACT:Objective To develop a novel drug dilivery system based on calcium phosphate cement (CPC) with methotrexate (MTX) as a model drug and to study its drug release in vitro.

摘要 摘要：目的 观察含甲氨喋呤（MTX）的磷酸钙骨水泥（CPC）的药物释放体系在体外模拟体液中的药物释放情况。

59. Abstract BACKGROUND & AIM: To study the DNA damage of BALB/c mice caused by multiple treatment with low-dose methotrexate (MTX)and the protective effect of folinic acid(FA).

摘要 背景与目的：研究多次低剂量应用甲氨蝶呤所致BALB/c小鼠淋巴细胞及骨髓细胞DNA的损伤，并探讨甲酰四氢叶酸对其损伤的保护作用。

60. AIM To explore the characteristics of adverse drug reactions (ADR) after intrathecal injection of methotrexate for leukemia in order to conduct the proper clinical application.

摘要目的探讨白血病病人鞘内注射甲氨蝶呤治疗白血病不良反应的发生规律，以期指导临床合理用药。

61. Objective To study the efficacy and safety of leflunomide (LEF) in the treatment of active rheuma-toid arthritis (RA) compared to methotrexate (MTX).

摘要目的研究来氟米特治疗活动期类风湿关节炎的临床疗效和安全性。

62. Objective: To investigate the effect of methotrexate (MTX) combined with Shaofuzhuyu decoction in the treatment of unruptured ectopic pregnancy.

摘要目的：探讨甲氨蝶呤(MTX)、中药少腹逐瘀汤联合治疗未破裂型异位妊娠的效果。

63. Objectives To assess the clinical efficacy and safety of plasma exchange combined with methotrexate (MTX) and sulfasalazine (SSZ) in the treatment of severe rheumatoid arthritis (RA).

摘要目的：评价血浆置换联合甲氨蝶呤(MTX)、柳氮磺胺吡啶(SSZ)与单纯甲氨蝶呤、柳氮磺胺吡啶治疗重症类风湿关节炎的疗效与安全性。

64. Methods: Document of combining methotrexate(MTX)with mifepristone treatment for 40 cases of ectopic pregnancy were analyzed retrospectively.

方法:回顾性分析40例甲氨喋呤(MTX)联合米非司酮治疗异位妊娠的疗效。

65. Methods:7 patients with carcinoma of tongue were treated by Pingyangmycin and Methotrexate via the cannula of lingual artery.Size of carcinoma was measured before and after therapy.

方法:运用舌动脉插管,对7例舌癌患者给予化疗药物平阳霉素和甲氨蝶呤,治疗前定点并测量溃疡面大小,治疗结束后再次测量溃疡面大小。

66. Methods:We managed a cervical pregnancy by local injection of methotrexate(MTX)assisted by hysteroscopy and literatures were reviewed.

方法:采用宫腔镜技术定位诊断并直视下局部注射甲氨喋呤(MTX)治疗1例宫颈妊娠患者及文献复习。

67. Methods There were 44 cases in group of mifepristone and 45 cases in group of mifepristone combined with methotrexate.

方法米非司酮组44例,米非司酮配伍甲氨喋呤组45例。

68. Methods: Document of combining methotrexate (MTX) with mifepristone treatment for 40 cases of ectopic pregnancy were analyzed retrospectively.

方法：回顾性分析40例甲氨喋呤(MTX)联合米非司酮治疗异位妊娠的疗效。

69. Gervaise A, Capella-AlloucS, Audibert F, et al. Methotrexate for the treatment of unruptured tubal pregnancy: a prospective nonrandomized study[ J ]. JSLS, 2003,7 (3) : 233 - 238.

曹永利.甲氨蝶呤米非司酮用于宫外孕保守治疗对照研究[J].山西医药杂志,:.

70. Methotrexate (MTX) was considered individually and, as the most widely prescribed immunosuppressive agent, used as the reference group for other therapies.

最常使用的免疫抑制剂MTX作为对照组被单独评估。

71. One day it all of a sudden pain in your body methotrexate singing, I write poetry, not monologue.

有一天它忽然痛了，在你体内呤唱着，我撰写不出的独白诗集。

72. There are reports, the treatment of ankylosing spondylitis in the柳氮drug sulfasalazine, methotrexate, Tripterygium has a certain impact on the gonads, but is reversible.

有报道，治疗强直性脊柱炎药物中的柳氮磺胺吡啶、甲氨蝶呤、雷公藤对性腺有一定影响，但均是可逆的。

73. Sometimes both chemotherapy (methotrexate, cytarabine and hydrocortisone) and radiation therapy are used.

有时候，化疗（甲氨蝶呤、阿糖胞苷和皮质醇）和放疗可以同时使用。

74. Before operation,the patients accepted one cycle of CMF chemotherapy(cyclophosphamide,600 mg/m 2 i.v. d1 and d8;methotrexate,30 mg/m 2 i.v. d1 and d8;5 Fluorouracil,500 mg/m 2 i.v. d1 and d8).

术前化疗采用CMF 方案（CTX600 m g/ m 2，静脉推注，第1 天和第8 天；MTX 30 m g/ m 2，静脉推注，第1 天和第8 天；5?Fu 500 m g/ m 2 静脉滴注，第1 天和第8 天）1 个疗程化疗后，进行手术。

75. Methotrexate or leflunomide monotherapy should be started for patients with all disease durations and for all degrees of disease activity irrespective of poor prognostic features.

来氟米特或甲氨蝶呤单药治疗被推荐用于任何病程以及任何疾病活动度的患者的初始治疗，不论患者是否具有预后不良的特征表现。

76. Treatment of active ankylosing spondylitis with leflunomide and methotrexate: a prospective controlled clinical trial

来氟米特治疗活动性强直性脊柱炎的疗效与安全性研究

77. Observation of the efficacy of leflunomide and methotrexate in the treatment of rheumatoid arthritis

来氟米特治疗类风湿关节炎的临床疗效评价

78. A combination of a TNF-alpha blocker and methotrexate a standard antirheumatic drug is twice as effective as methotrexate alone in the treatment of rheumatoid arthritis.

标准抗风湿药甲氨喋呤与肿瘤坏死因子-alpha的阻断物的合剂是原来功效的2倍。

79. The seperated neoplastic drug workshop is producing APIs of Methotrexate, Ifosfamide and other neoplastic APIs.

根据国家药品监督管理局的要求，我厂冻干粉针剂车间（抗肿瘤药）、片剂、原料药（含抗肿瘤药）车间已通过GMP认证。

80. Intraspinal commonly used drug methotrexate and cytarabine.

椎管内常用的药物有甲氨喋呤及阿糖胞苷。