paromomycin

paromomycin

1. To provide a more convincing positive control for our system, we used paromomycin which suppresses stop codons by reducing elongation fidelity.

为使我们的系统拥有一个更具说服力的阳性对照，我们使用了能通过降低翻译延长精确度来抑制终止密码子作用的巴龙霉素。

2. Luciferase expression in E. coli/pLux1 was not affected by paromomycin at sub-growth inhibitory concentrations.

反之，在低于生长抑制的浓度下，巴龙霉素不影响大肠杆菌pLux1基因荧光素酶的表达。

3. If WHO's antibiotic, paromomycin, could be deployed, it might be used on an outpatient basis at a cost of $1 a day, eliminating the parasite in three weeks.

如果WHO的巴龙黴素能够通过核可的话，将可于门诊中使用，而且每天的花费仅约一美元，三周之内就可以消灭寄生虫。

4. When paromomycin was used at 2.5 Ag/ml, luciferase activity was elevated 8- and 10-fold in E. coli/pLux2 (UAG) and pLux3 (UAA) relative to untreated cells.

当巴龙霉素的浓度达到2.5Ag/ml时，相对于未处理的对照组细胞，大肠杆菌/pLux2(UAG)和大肠杆菌/pLux3(UAA)的荧光素酶活性增加了8-10倍。

5. Gentamicin and paromomycin increased luciferase activity up to 2.5- and 10-fold, respectively.

抑制的作用机制很可能和通读的增强有关，但此假设还需要进一步验证。

6. paromomycin sulphate tablet

硫酸巴龙毒素片

7. paromomycin sulfate

硫酸巴龙霉素

8. Paromomycin concentrations above 2.5 Ag/ml led to a significant decrease in E. coli growth.

结果表明，浓度高于2.5Ag/ml的巴龙霉素能显著抑制大肠杆菌的生长。

9. A dose response was observed between increasing paromomycin concentration and luciferase activity in E. coli/pLux2 and pLux3.

随着巴龙霉素浓度的增加，大肠杆菌/pLux2和大肠杆菌/pLux3的荧光素酶活性具有剂量相关性。