phosphorylation

phosphorylation

1. 2). CDK activation by phosphorylation.

2）CDK磷酸化后被活化。

2. 3). CDK inhibition by phosphorylation.

3）去磷酸化抑制CDK活性。

3. Aurora-B can phosphorylate Septin 1.Ser-307 and Ser-315 is its important sites of phosphorylation.

Aik2可磷酸化 Septin1，Ser-307、315是重要的磷酸化位点。

4. Decrease of AKT phosphorylation affects the activity of glucose transporter-4（GLUT-4） which translocates the glucose into cells, so the level of blood glucose increases.

AKT磷酸化的降低即活性的降低导致葡萄糖转运因子4（Glucose Transporter-4，GLUT-4）的活性降低，最终影响血液中葡萄糖向细胞内的转运，表现出血糖升高的生理现象。

5. EFFECT OF CDK-5 OVEREXPRESSION ON TAU PHOSPHORYLATION

Cdk-5过度表达对Tau蛋白磷酸化的影响

6. The Effect of cdk-5 Overexpression on Neurofilament Phosphorylation

cdk-5过度表达对神经细丝磷酸化的影响

7. CPF also inhibited M2 re- ceptors phosphorylation,but was less potent and less efficacioas than that of CPO. PO and parathion(PT)had little ef- fect on the receptor phosphorylation under the same conditions.

CPF也抑制mAChR2的磷酸化,而PO与对硫磷(PT)不抑制mAChR2的磷酸化。

8. CREB as a transcriptional regulation factor in eucaryotic cell carrie s out the function by itself phosphorylation.

CREB是一种细胞核内调控 因子，它通过自身磷酸化实现调节转录的功能。

9. DHT produced fast and transient increases in intracellular Ca~(2+) in a concentration-dependent manner, and quickly induced phosphorylation of ERK1/2 and JNK, but phosphorylation of p38 was inhibited in prostate cancer PC3 cells.

DHT可以在一定范围内浓度依赖性地诱导PC3细胞[Ca~(2+)]i快速升高,而且也能快速诱导ERK1/2、JNK的磷酸化,但是对p38的磷酸化却表现为快速的抑制作用;

10. The primary structure of DOC-2 reveals that DOC-2 is a putative signaling molecule with protein-protein interaction and protein phosphorylation as two possible mechanisms modulating its activity.

DOC-2/DAB2的主要结构提示DOC-2/DAB2是一种可能的信号分子，通过蛋白质第四军医大学博士学位论文5一蛋白质相互作用和蛋白磷酸化两种机制发挥作用。

11. These results indicate that EETs and epoxygenases not only up regulate eNOS protein expression but also increase phosphorylation of eNOS at Thr 495 site, which may affect eNOS function.

EETs和CYP表氧化酶不仅能明显促进血管内皮细胞总eNOS蛋白的表达 ,而且还通过其翻译后修饰来增加其Thr 4 95位蛋白磷酸化水平

12. With phosphorylation by Ca 2+ calmodulin (CaM), Bmax was decreased in both shamoperation and IRI groups(both P <0 05), but was less decreased in the latter( P <0 01).

IRI组和 Sham组心肌细胞核经 Ca2 +钙调素 (Ca M)处理后 ,Bm ax均降低 (P均 <0 .0 5 ) ,但 IRI组降低幅度较小 (P<0 .0 1) ;

13. Leigh syndrome is a severe early-onset progressive neurodegenerative disorder due to mitochondrial oxidative phosphorylation defects.

Leigh综合征是一种由于线粒体氧化磷酸化障碍所导致的严重退行性脑病。

14. LPS can induce the protein phosphorylation of ERK1/2 and p38MAPK of KCs or liver, but had few effect on the protein expression.

LPS可促进肝脏或KCs ERK1/2、p38MAPK蛋白磷酸化，但对ERK1/2、p38MAPK蛋白表达无明显影响。

15. MEKK2 also synergized with anti-CD3 antibody to activate JNK in T cells, and stimulation of T cells led to induction of MEKK2 tyrosine phosphorylation.

MEKK2也是JNK的强烈激活物，能激活JNK依赖的AP-1和IL-2报告基因表达。 当用抗CD28抗体刺激时MEKK2介导的JNK活性无变化，而随着抗CD3抗体刺激，MEKK2介导的JNK活性显著增加。

16. PIF1, PIF3, PIF4 and PIF5 are degraded in response to light signals, and physical interaction of PIF3 with phytochromes is necessary for the light-induced phosphorylation and degradation of PIF3.

PIF1、PIF3、PIF4和PIF5在对光信号的应答中降解，同时，与光敏色素的结合也是PIF3光诱导磷酸化和降解所必须。

17. Phosphorylation of p21~(WAF) by PKA affects its ubiquitination and stability

PKA磷酸化p21~(WAF)后对其泛素化修饰和稳定性的影响

18. S(+)-Ket inhibits the phosphorylation of p47phox of NADPH oxidase subunit and the superoxide generation in human neutrophils via PKC-calcium signal pathway.

S(+)-Ket通过PKC-钙信息通道,抑制NADPH氧化酶p47phox,抑制超氧阴离子的产生。

19. SAB and Curcumin could significantly inhibit the proliferation,activation and ERK phosphorylation.

SAB和Cur能够抑制HSC的增殖、活化和ERK的磷酸化。

20. Although both Ser/Thr and Tyr phosphorylation play a crucial role in cellular regulation in animals, only Ser/Thr phosphorylation has been proved to be an important regulatory mechanism in plant cells.

Ser/Thr和Tyr磷酸化在动物和酵母细胞的生长发育过程中都起重要的作用,但在植物细胞中仅确立了Ser/Thr磷酸化作用。

21. Through b ind ing to its receptor,TPO can induce receptor d im eriza-tion and tyrosine phosphorylation,and then activate a series of signaling pathways,inc lud ing JAK /STAT,Shc /Ras/MAPK and PI3K /Akt.

TPO与其受体c-Mp l结合后,c-Mp l形成同源二聚体,激活JAK/STAT、Shc/Ras/MAPK、PI3K/Akt等信号通路,引发一系列生理效应。

22. Deltamethrin was found to affect ATPase activity and protein phosphorylation of housefly brain synaptosome in vitro .

为材料，研究和比较了神经毒剂溴氰菊酯对其脑突触体蛋白磷酸化作用的影响。

23. acetyl glyceryl ether phosphoryl choline

乙酰甘油醚磷酰胆碱:血小板活化因子

24. serine/threonine phosphorylation

人中性白细胞

25. Insecticide chlorphoxim was prepared from 2-chlorotoluene by chloration,cyanation,oximation and phosphorylation.

以邻氯甲苯为原料，经氯化、氰化、成肟和磷酰化反应，制得氯辛硫磷。

26. After treatment of MNC of CML and K562 with imatinib in vitro, the expression of DNA-PKcs protein was enhanced while tyrosine phosphorylation of bcr-abl fusion protein decreased.

伊马替尼体外作用于CML患者MNC及K562细胞后,DNA-PKcs蛋白表达量随着bcr-abl融合蛋白酪氨酸磷酸化水平的降低而升高。

27. Effects of Low Temperature Stress on Physiological Index and Protein Phosphorylation in Brassica oleracea L.

低温对甘蓝逆境生理指标和蛋白质磷酸化的影响。

28. pendant phosphoryl choline group

侧基磷酰胆碱基

29. Furthermore, infrared spectrophotometer was used to make infrared absorption spectroscopy for unmodified and modified casein, through comparison we found that phosphorylation brings s.

做出了红外吸收图谱,通过两图对比可以看出磷酸化给酪蛋白的结构带来的变化。

30. photosynthetic phosphorylation

光合磷酸化作用

31. cotranslational phosphorylation

共翻译磷酸化

32. Keywords NR1;phosphorylation;hypoxia-ischemia;SD rat;brain;

关键词NR1;磷酸化;缺氧缺血;新生鼠;脑;

33. Keywords Multi-cerebral infarction;MARCKS;Phosphorylation;

关键词多发性脑梗塞;MARCKS;磷酸化;

34. The mechanism of action was proved to be reversible phosphorylation and dephosphorylation.

其作用机理亦是通过可逆的磷酸化及脱磷酸化作用进行的。

35. The mechanisms of its activation and translocation may be associated with the difference of the activation factors or its targets, and the amino acid residues of different phosphorylation site.

其激活和转位机制可能与其不同的活化因子或底物和不同位点的氨基酸残基磷酸化有关。

36. Western blot analysis suggested the decreased cell motility might be attributed to the reduced phosphorylation of focal adhesion kinase (FAK) by PTEN gene delivery.

利用西方墨点法分析可以推测经PTEN基因传送的肝癌细胞移行数目的减少，可能是因降低了FAK磷酸化的缘故所致。

37. With 2,4-dinitrophenol (DNP) as an uncoupling agentof oxidative phosphorylation,glycolysis of PEP was increased with increase in theconcentration of DNP added.

加入氧化磷酸化的解联剂2,4-二硝基酚(DNP),可使PEP 的酵解随DNP 浓度的增加而增加;

38. We observed treatment with anti-CD28 induced distinct increase in phorsphorylation of NFAR1 at Ser647 and AKT phosphorylation was up-regulated coincidently.

发现CD28刺激后，NFAR1的磷酸化水平明显增加，而且这种增加是伴随着AKT磷酸化水平增加的；

39. reversible protein phosphorylation

可逆性蛋白磷酸化

40. When oxygen levels drop, oxidative phosphorylation slows and ATP levels decrease.

含氧量下降时，氧化磷酸化的速率会减缓，ATP含量就跟著下降。

41. respiratory chain phosphorylation

呼吸链磷酸化

42. In cultured endothelial cells, knockdown of GIT1 decreased VEGF-mediated phosphorylation of PLC and ERK1/2.

在培养的内皮细胞内，GIT1敲除降低了VEGF介导的PLC和ERK1/2的磷酸化。

43. It is also fair to say that Ser-2808 phosphorylation could still hae functional consequences in HF, een if it is not purely PKA-dependent.

在心衰患者，Ser-2808的磷酸化仍对心功能有影响，即使不纯粹是PKA依赖的。

44. Uridine-cytidine kinase (UCK) (EC 2.7.1.48) is a pyrimidine ribonucleoside kinase that catalyzes the phosphorylation of uridine and cytidine to UMP and CMP.

在本论文的第一章中主要是对人类尿苷胞苷激酶（UCK，EC 2.7.1.48）基因进行的一系列研究。

45. In certain occasions, CDK-mediated phosphorylation of checkpoint proteins is required to activate their DNA-repair mediator function.

在某些情况下，蛋白激酶介导的关卡蛋白的磷酸化作用需要激活他们的DNA修复调节功能。

46. Phosphorylation of postsynaptic density proteins remains a largely unexplored mechanism in activity-dependent regulation of dendrite development and synaptic function.

在树突发育和突触功能活性依赖的调节过程中，突触后致密蛋白磷酸化的机制仍然是未知的领域。

47. In vivo treatment with AMPAR antagonists blocked increases in phosphorylation, EPSC amplitude, and EPSC frequency, and also attenuated susceptibility to later seizures.

在活体治疗中阻断AMPAR拮抗剂可增加磷酸化，增加EPSC振幅与频率，同时也减轻了后天癫痫发作的损伤。

48. In eukaryotic organisms, energy production in the form of oxidative phosphorylation (OXPHOS) is the only process under control of both nuclear and mitochondrial ge-nomes.

在真核生物中，产生能量的氧化磷酸化过程是唯一一个受到核基因和线粒体基因双重调控的过程。

49. The stability and activity HIF are strictly regulated in cells by such processes as hydroxylation, ubiquitination, acetylation, phosphorylation and sumoylation.

在组织细胞中缺氧诱导因子家族蛋白稳定性与活性受到严密的调节,主要方式有:羟基化、泛素化、乙酰化、磷酸化、小泛素样因子修饰。

50. Conclusions Intravenous administration of the MEK inhibitor U0126 inhibits MEK, ERK1, ERK2 and Elk-1 phosphorylation and activation induced by cerebral ischemia.

在缺血前20分钟注射U0126可抑制ERK1和ERK2的磷酸化，缺血后即刻或缺血20分钟后注射无抑制作用。

51. Protein phosphorylation, which is mediated by enzymes, called protein kinases, is a major mechanism for transducing external stimuli into intracellular signals.

在这其中，把细胞外刺激转导到细胞内是通过蛋白质磷酸化来完成的，而蛋白质磷酸化又被蛋白激酶介导。

52. In rat hippocampal slices, TBS induced phosphorylation of p21-actiated kinase (PAK) and its downstream effecter cofilin, signaling proteins that enable actin filament growth.

在鼠海马切片中，短暂快速脉冲刺激导致蛋白激酶21的磷酸化，在它的下游区产生了cofilin,一种能使肌动蛋白丝生长的信号蛋白。

53. Keywords Soy protein isolate （SPI） Phosphorylation Functionality;

大豆分离蛋白;磷酸化;功能特性;

54. How many different CTD serine phosphorylation patterns are present in cells, and are these phosphorylated isomers functionally distinct?

大部分研究迄今为止一直致力于CTD磷酸化在转录过程中的规则。

55. Such phosphorylation results in endothelial NO synthase activation, which provides a novel explanation for the pleiotropic effects of statins that benefit the cardiovascular system.

如此磷酸化导致内皮NO合酶激活，为他汀类药物有益心血管系统的多效性提供了一个新的解释。

56. The results showed that CCL4and HG inhibited the GK activity,elevated Caconcen tration and decreased the level of tyrosine phosphorylation in hepatocytes.

实验结果表明,CCL4和HG均使肝细胞内葡萄糖激酶活性下降,Ca超载,并使细胞内酪氨酸磷酸化水平降低.

57. Treatment with CHEL significantly increased hCG accumulation in JAR cells, and enhanced the phosphorylation of MAPK.

对照组及各实验组都有活性的MAPK的表达,与对照组相比,PMA慢性刺激组、CHEL组MAPK磷酸化水平升高; PMA急性刺激组MAPK磷酸化水平降低。

58. STUDY ON THE PHOSPHORYL ATION OF WHEAT GLUTEN

小麦面筋蛋白的磷酸化改性研究

59. It has been proven that KSR has many phosphorylation sites, and phosphorylation state changes response to signaling events.

已有的研究表明KSR有许多磷酸化位点,这些位点磷酸化状态的改变与外界信号刺激有着极为密切的关系。

60. Phosphorylation of extracellular signal-regulated kinase(ERK)1/2 was assessed by Wes-(tern) blotting.

应用ERK1/2抑制剂PD98059预处理,观察CTGF对上清液中MCP-1分泌的影响。

61. The tyrosine phosphorylation of leptin receptor was revealed by immuno precipitation.

应用免疫沉淀法检测瘦素受体的酪氨酸磷酸化程度。

62. substrate level phosphorylation

底物水平磷酸化

63. substrate-level phosphorylation

底物水平磷酸化作用

64. The monitoring methods to detect phosphoric acid fume in phosphorylation workshop was made up with perchloroethylene filter membrane sampling acid digestion molybdenumblue spectrophotometry.

建立了过氯乙烯滤膜采样 -酸消解 -钼蓝分光光度法测定磷化车间磷酸雾的监测方法。

65. Gordon have demonstrated that mechanical loading of skeletal muscle will induce activation of FAC signaling, as determined by changes in the phosphorylation status of FAK or paxillin.

戈登已经表明，骨骼肌机械装载外交事务委员会活化诱导信号，如在FAK的或桩蛋白磷酸化状态的变化决定的。

66. S127 and S166 of RNF4 are important phosphorylation sites in RNF4-mediated CAAT-box activation by PKA.

我也发现S127、S166是蛋白质激酶PKA磷酸化的重要位置。

67. Overexpression of wild-type Ras enhanced CpG ODN-induced ERK, JNK and NF-xJB reporter gene activation, On the contrary, RasN17 transfection inhibited CpG ODN-induced ERK1/2 and JNK1/2 phosphorylation and NF-KB reporter gene activation.

我们用免疫沉淀实验发现CpG ODN还能诱导Ras与TLRg的结合。 同样条件下non一CpG既不能活化Ras，也不能诱导Ras/T LRg复合物的形成，提示Ras活化以及Ras与TLRg的结合具有CpG基序特异性。

68. We examined the response of rat pulmonary artery (PA) rings to 15-HETE, the production of NO, total eNOS expression and the phosphorylation of eNOS in bovine pulmonary artery endothelial cells (BPAECs) stimulated by 15-HETE.

我们通过Wistar大鼠肺动脉环张力、牛肺动脉内皮细胞NO产量、总eNOS 表达及eNOS磷酸化测定等方法对15-HETE与eNOS/NO的相互作用进行研究。

69. Rather, I will address the functional consequences of enhanced RyR2 Ca2+ sensitiity which hae been suggested for some phosphorylation effects (PKA and CaMKII) and also for some CPT mutations.

我宁可叙述一下RyR2对钙离子敏感性增高的功能性影响，这被认为是某些PKA和CaMKII的磷酸化效应，儿茶酚胺能的多形性室性心动过速患者的突变。

70. All MAPKs contain a threonine -X-tyrosine motif and require phosphorylation of both threonine and tyrosine for activation.

所有的MAPK都含有一个苏氨酸-X-酪氨酸基序,并需要在苏氨酸及酪氨酸两者都被磷酸化之后才能激活。

71. Keywords Antitumor agent;Phosphoramide;Phosphoryl diamide;

抗癌药物;磷酰胺;磷酰二胺;

72. And the encoded protein was a membrane protein with two transmembrane helical regions containing 4 function domains, 1 PKA phosphorylation site and 2 N-glycosylation sites.

拓扑结构为两次跨膜蛋白,具有4个功能结构域,含有1个磷酸化位点及2个N-糖基化位点.

73. Alternatiely, the induction of anergy results in markedly less S6 kinase 1 Thr(421)/Ser(424) phosphorylation and CD71 surface expression.

换之,无能可导致明显地S6激酶1在421位苏氨酸/424位丝氨酸磷酸化和CD71胞膜表达的减少.

74. Abstract: Regulation of specific proteins by phosphorylation is usually overlooked by standard loss-of-function approaches such as RNAi or gene knockout, which simply remove the gene or protein.

摘 要： 常规 R NA 干涉或基因敲除的功能缺失手段仅仅只是简单地移除某个基因或蛋白，而这个过程常常会掩盖磷酸化对某个特定蛋白的调节。

75. Abstract: Mitochondrion is the basic and important organelle in most of the eukaryocyte, It is the place of oxidative phosphorylation.

摘要: 线粒体是存在于绝大多数真核细胞内的一种基本的、重要的细胞器，是细胞进行氧化磷酸化的场所。

76. The research aimed to improve the fire retardant properties of wood through treatment with phosphoryl triamides.

摘要本研究目的在于以磷醯三胺化合物改善木材之耐燃性质。

77. Phosphorylation is an important protein chemical modification which plays vital roles in completion and change of protein function.

摘要磷酸化修饰是一种重要的蛋白质化学修饰，对蛋白质功能的完成或改变起到重要作用。

78. Keywords nucleophosmin/B23;actinomycin D;cell cycle phase;phosphorylation;

放线菌素D;细胞周期;磷酸化;

79. Methods After exposure to 5 W/cm~2 microwave, the change of PKC kinase activity in rat hippocampus was detected by Takai method, AMPA receptor phosphorylation level was determined by Western-blotmethod.

方法以峰值功率密度为5W/cm2的微波持续辐照大鼠1,3,5,10,15d,用改良的Takai法检测海马PKC活性,用Western-blot法检测海马AMPA受体磷酸化程度。

80. METHODS Vidarabine monophosphate was synthesized by vidarabine phosphorylation directly in the present of pyridine and acetonitrile.The pure products were obtained by crystallization.

方法直接以阿糖腺苷为原料,对其进行磷酸化,经过精制纯化,得到单磷酸阿糖腺苷。