spironolactone

spironolactone

1. The Effects of a Low dose of Spironolactone combined with ACEI on the Turnover of Myocardial Collagen

ACEI联合小剂量安体舒通对原发性高血压胶原更新的临床实验研究

2. FN mRNA expression was increased by 1.03 fold of Con (P<0.05), spironolactone and DMA could inhibit this effect to 91.21% and 92.30% of Aldo respectively (P<0.01).

Aldo+Spir组和Aldo+DMA组FN mRNA水平有所下降,分别是Aldo组的91.21%(P<0.01)和92.30%(P<0.01)。

3. CAO WZ, MENG H, SUN Y, et al.Angiotensin-converting enzyme inhibctor and spironolactone treating refractory heart failure [J].Linchuang Huicui, 1998, 13(4): 661-662.

[1]曹文智,孟辉,孙宇,等.血管紧张素转换酶抑制与螺内酯联合治疗难治性心力衰竭[J].临床荟萃,1998,13(4):661-662.

4. CHEN B,DU FH,LI BQ.The effects of spironolactone on some neurohormonal factors in patients with heart failure secondary to dilated cardiomyopathy[J].Chinese Circulation Journal,2004,19:409-411.

[4]陈斌,杜凤和,李帮清.螺内酯对扩张型心肌病心力衰竭患者某些体液因子的影响[J].中国循环杂志,2004,19:409-411.

5. Compared to the controls, in low dosage of spironolactone group, protein cast and inflammatory cells infiltration around tubules reduced (P<0.05);

与高血压组比较，低剂量螺内酯干预后，蛋白管型增多、管周炎性细胞浸润均减少（P <0.05）；

6. Another 93 subjects were treated by herbs adding with E2,P,CC,HCG,HMG,BCT,Diane-35,spironolactone respectively,accounts for 78.81%.

中药分别加用E2、P、CC、HCG、HMG、BCT、达因-35、安体舒通治疗者93例,占78.81%。

7. As a result, spironolactone become China's first research to the molecular level of cancer drugs.

于是，安体舒成为我国首个研究到分子水平的癌新药。

8. However, the value of combining spironolactone with an angiotensin II receptor blocker on LV reverse remodeling in mild-to-moderate systolic HF is unclear.

但是，对轻中度收缩性HF患者，螺内酯联合血管紧张素II受体拮抗剂对左室（LV）逆重构的价值目前还不清楚。

9. The most commonly encountered side effect of spironolactone is orthostatic dizziness on getting up quickly or suddenly bending oer.

使用安体舒通最常见的副作用是快速起身或突然弯腰引起的体位性眩晕。

10. A real data set from near -infrared diffuse reflectance spectra of spironolactone pharmaceutical powder was used to built up an artificial neural network model to predict unknown samples.

使用安体舒通粉末药品的近红外漫反射光谱数据建立人工神经网络模型，预测未知样品。

11. Eplerenon, a derivative of spironolactone, is the first selective aldosterone receptor antagonist.

依普利酮是一种螺内酯的衍生物,并且是第一种具有选择性的醛固酮受体拮抗剂。

12. Keywords congestive heart failure;Aldosterone;Spironolactone;Aldosterone antagonist;

充血性心力衰竭;醛固酮;螺内酯;醛固酮阻断剂;

13. Keywords coronary heart disease;chronic heart failure;spironolactone;triamterene;

关键词冠心病;慢性心力衰竭;螺内酯;氨苯喋啶;

14. Keywords Spironolactone;UUO;oxidative stress;Fibrosis;

关键词安体舒通;UUO;氧化应激;纤维化;

15. Keywords Valsartan;Spironolactone;Essential hyperten sion;Myocardial extracellular matrix;

关键词缬沙坦;安体舒通;原发性高血压;心肌细胞外基质;

16. Keywords Valsartan;Spironolactone;Hepatocyte growth factor;Gene expression;

关键词缬沙坦;螺内酯;肝细胞生长因子;基因表达;

17. Keywords Spironolactone Heart failure Brain natriuretic peptide Atrial natriuretic peptide Angiotensin Aldosterone;

关键词螺内酯;心力衰竭;脑钠素;心钠素;血管紧张素;醛固酮;

18. The mechanism of the effects of spironolactone on the endocrine system is unclear.

其对内分泌系统的影响机制尚不清楚。

19. Secondary objecties were to compare the dose response for each diuretic and to ealuate amiloride as an alternatie to spironolactone.

其次我们比较了每一种利尿药的剂量反应并对阿米洛利作为安体舒通的替代药物进行药效评估。

20. Spironolactone used alone can kill tumor cells, suppression, narrow lesions to prevent metastasis and recurrence;

单独使用安体舒，可抑杀肿瘤细胞，缩小病灶，阻止转移与复发；

21. Spironolactone can be seen directly kill cancer cells, block tumor cell growth and proliferation and safety exceed the current listing of any drugs.

可见安体舒直接杀灭癌细胞、阻止肿瘤细胞的生长和增殖及其安全性超过目前上市的任何药物。

22. Howeer, spironolactone was the more effectie natriuretic agent, suggesting that inappropriate aldosterone release or response may still contribute to the Na+ retention of low-renin hypertension.

因为此结果不同于对原发性醛固酮增多症患者预期的结果，我们的发现不支持低肾素性高血压包括一大群未诊断的原发性醛固酮增多症患者。

23. Keywords Polycystic ovarian syndrome;Infertility;Ethinyl estradiol and cyproterone acetate;Spironolactone;

多囊卵巢综合征;不孕;复方醋酸环丙孕酮;安体舒通;

24. If potassium rises to 6.0 mmol/L stop spironolactone (or eplerenone)immediately and monitor blood chemistry closely;

如血钾升至6.0mmol/L，立即停用安体舒通（或依普利酮），并密切监测血生化；

25. The most commonly used treatment is spironolactone in combination with OCP.

安体舒通与口服避孕药联用是最常用的治疗方法。

26. Two doses each of spironolactone and bendroflumethiazide were compared.

安体舒通和苄氟噻嗪组均分为两个剂量组进行比较。

27. Spironolactone in treatment of acne vulgaris

安体舒通治疗寻常痤疮疗效观察

28. NHE1 mRNA expression was increased by 1.16 fold of Con(P< 0.05), and spironolactone could inhibit this effect to 81.9% of Aldo(P< 0.05).

实时PCR结果显示Aldo组NHE1 mRNA水平有所增高,是对照组的1.16倍(P<0.05),而Aldo+Spir组NHE1 mRNA水平明显下降,是Aldo组的81.9%(P<0.05)。

29. Pairs of male animals to the human body of 2.2 times the amount of spironolactone, no increase in the rate of sperm deformity.

对雄性动物给人体用量的2.2倍安体舒，精子畸形率未见升高。

30. Low doses of digoxin, captopril, metoprolol and spironolactone in combination in treatment of elderly cardiac insufficiency

小剂量地高辛、卡托普利、美托洛尔、螺内酯联用治疗老年心力衰竭

31. Spironolactone with Betaloc is effective and safety mean for treating chronic heart failure induced by CHD and HHD.

小剂量螺内酯联用倍他乐克配合常规治疗用于冠心病及高血压性心脏病慢性心力衰竭的疗效显著、安全、价廉。

32. Evaluation of therapeutic effects of spironolactone on schistosomal pulmonary arterial hypertension by echocardiography

应用超声心动图观察螺内酯对血吸虫性肺动脉高压的疗效

33. HPLC method for simultaneous determination of clindamycin and spironolactone in compound clindamycincream was established.

建立高效液相色谱法同时测定复痤霜中克林霉素和螺内酯的含量。

34. Keywords myocardial infarction;ventricular remodeling;heart function;matrix metalloproteinases;collagen;valsartan;spironolactone;

心肌梗死;心室重构;心功能;基质金属蛋白酶;胶原;缬沙坦;安体舒通;

35. Keywords myocardial infarction;ventricular remodeling;collagen;hemodynamic;spironolactone;losartan;

心肌梗死;心室重构;心肌胶原;血流动力学;螺内酯;氯沙坦;

36. Keywords heart failure;regular treatment;spironolactone;

心衰;常规疗法;螺内酯;

37. Method:The patients were 127cases.Treated group was 64 patients who were injected into the veins by Dopamine and Phentolamine and took Furosemide and Spironolactone.

方法:选择肝硬化并发腹水者127例,治疗组64例,用多巴胺、酚妥拉明静脉滴注,口服速尿片、安体舒通;

38. AMI rats were randomly divided into sham operation group, AMI group,spironolactone group (S), losartan group (L), combination group(S+L).

方法将AMI大鼠模型随机分成假手术组、AMI对照组、螺内酯组(S组)、氯沙坦组(L组)及合用组(S+L组)。

39. In addition, spironolactone is reported to inhibit binding of dihydrotestosterone to receptors.

此外，有报道螺内酯是通过抑制双氢睾酮和其受体的结合来发挥其药理效应。

40. Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism: A randomized controlled study

氟他胺与螺内酯联合达英35治疗特发性多毛症临床疗效比较的随机对照研究

41. Clinical Evaluation on Therapeutic Alliance with Dihydrochlorothiazide and Enalapril and Metoprolol and Spironolactone for Dilated Cardiomyopathy in Children

氢氯噻嗪、依那普利、美托洛尔、螺内酯联合治疗扩张型心肌病疗效评估

42. Keywords Azone;clindamycin hydrochloride;spironolactone;percutaneous absorption;

氮酮;盐酸克林霉素;螺内酯;透皮吸收;

43. Effects of Azone on the Percutaneous Absorption of Clindamycin Hydrochloride and Spironolactone in Acne Treatment Cream

氮酮对消痤乳膏中克林霉素和螺内酯透皮吸收作用的研究

44. NHE1 protein abundance was increased by 2.9 fold of Con(P< 0.01), and spironolactone could inhibit this effect to only 52.3% of Aldo (P < 0.05).

流式细胞术结果显示Aldo组NHE1蛋白水平显著增高,是对照组的2.9倍(P<0.01),而Aldo+Spir组NHE1蛋白水平明显下降,仅为Aldo组的52.3%(P<0.05),安体舒通本身对NHE1的基因和蛋白表达没有显著影响。

45. With palms in the abdomen揉搓Massage, will be able to help digestion and elimination of sedimentation, Yiqi to keep fit, spironolactone visceral meridian.

用手掌在腹部揉搓按摩，能助消化，消除淤积，益气强身，舒通内脏经络。

46. Modern treatment of ascites is based on this recognition and includes modest salt restriction and stepwise diuretic therapy with spironolactone and loop-diuretics.

目前的肝硬化腹水治疗基本上是限制盐的摄入和螺内酯、速尿利尿治疗。

47. Objective:The aim of this study was to investigate the effects of extra spironolactone on the aldosterone (Aldo) level and heart function in patients with heart failure treated with angiotensin-converting enzyme inhibitor (ACEI).

目的 :观察慢性心力衰竭 (心衰 )患者应用血管紧张素转化酶抑制剂 (ACEI)治疗中加用醛固酮受体拮抗剂螺内酯对血浆醛固酮和心功能的影响。

48. Aim The aldosterone receptor antagonist spironolactone has long been regarded as diuretic for the treatment of ascitis and portal hypertension.

目的 醛固酮受体拮抗剂螺内酯长期作为利尿剂用于减少腹水和降低门脉压的治疗，近年已初步证实螺内酯对CCl4所致大鼠肝纤维化有预防作用，但其作用机制尚不清楚。

49. Objective:The present study was designed to detect anti?fibrotic effects of low dose aldosterone(ALDO) receptor anatagonist?spironolactone (spiron) on the sustained hypertensive myocardial fibrosis induced by LNNA.

目的：探讨小剂量醛固酮受体拮抗剂安体舒通抗左旋硝基精氨酸（LNNA）诱导高血压心肌纤维化的可行性。

50. The first involves the use of the drugs lisinopril, carvedilol, spironolactone, and losartan to enhance reverse remodelling.

第一个阶段包括药物赖诺普利，卡维地洛、螺内酯和洛沙坦的应用，以提高逆转重塑。

51. Keywords Diabetic nephropathy;Urinary albumin excretion rate;Spironolactone;Benazepril;

糖尿病肾病;尿白蛋白排泄率;螺内酯;贝那普利;

52. Conclusions Large dosage of spironolacton can aggravate renal fibrosis maybe through up-regulating level of renal aldosterone and its receptor.

结论 大剂量螺内酯可以加重高血压肾脏纤维化，可能是通过上调醛固酮及其受体表达实现的。

53. Conclusion:The finding indicates that the spironolactone therapy can suppress myocardial fibrosis and improve left ventricular function in old patients.

结论 ：在老年人轻度心力衰竭患者小剂量螺内酯治疗可以起到抗心肌纤维化、改善心功能的作用。

54. Conclusion Spironolactone had some protective effects on pulmonary fibrosis, and aldosterone might play a role in the development of pulmonary fibrosis.

结论安体舒通对肺纤维化有一定的保护作用，醛固酮可能参与肺纤维化的发病过程。

55. Conclusions: The addition of spironolactone to candesartan has significant beneficial effects on LV reverse remodeling in patients with mild-to-moderate chronic systolic HF.

结论：坎地沙坦联合螺内酯治疗对轻中度慢性收缩性心力衰竭患者的LV逆重构有明显益处。

56. Conclusion: Combined use of spironolactone, enalapril and shengmai injection is effective and safe in treating chronic heart failure induced by hypertensive heart diseases.

结论：螺内酯、依那普利和参麦注射液联合治疗高血压性心脏病所致的慢性心衰，安全、有效，可推荐使用。

57. Effects of Valsartan and Spironolactone on Matrix Metalloproteinases, Collagen Metabolism and Heart Function in Post-myocardial Infarction

缬沙坦和安体舒通对急性心肌梗死后基质金属蛋白酶和胶原代谢以及心功能的影响

58. Therapeutic Results of Valsartan and Spironolactone on Patients with Essential Hypertension Complicated with Paroxysmal Atrial Fibrillation

缬沙坦联合螺内酯对高血压合并阵发性心房颤动的临床观察

59. Keywords liver cirrhosis;hypertension;portal;sodium/metabolism;spironolactone;diuretics;rats;therapeutics;

肝硬化;高血压;门静脉;钠/代谢;螺内酯;利尿剂;大鼠;治疗学;

60. Background: Add-on spironolactone therapy substantially improves clinical outcomes among patients with severe heart failure (HF) on standard therapy.

背景：接受标准治疗的重度心力衰竭（HF）患者加用螺内酯可以明显改善其临床预后。

61. Could be so significant to kill cancer cells, "Spironolactone" Quedui does no harm to normal cells, so that the medical profession is also very surprised.

能如此显著杀灭癌细胞的“安体舒”却对正常细胞没有伤害，让医学界人士也感到十分惊讶。

62. Spironolactone ;Captopril ;Sicca Syndrome ;Therapeutic procedure ;therapeutic aspects ;

螺内酯 ;

63. Effects of Spironolactone, Losartan and Combination Therapy on Myocardial Angiogenesis during the Early State of Post Myocardial Infarction in Rats

螺内酯,氯沙坦及二者合用对急性心肌梗死大鼠早期新生血管的影响

64. Keywords Spironolactone;Unilateral ureteral obstruction;Renal tubulointerstitial fibrosis;

螺内酯;单侧输尿管梗阻;肾间质纤维化;

65. Keywords spironolactone;captopril;carvedilol;heart failure;congestive;rats;

螺内酯;卡托普利;卡维地洛;心力衰竭;充血性;大鼠;

66. Keywords spironolactone;cardiac insufficiency;catecholamine;cardiomyopathy;

螺内酯;心力衰竭;儿茶酚胺;

67. Keywords Spironolactone;Cryoinjury and necrosis;Myocardium Remodeling;Cadiocyte apoptosis;Ultramicrostructure;

螺内酯;心肌冷冻损伤坏死;心肌重构;心肌细胞凋亡;超微结构;

68. Keywords Spironolactone;Acute myocardial infarction;Heart function;P wave dispersion degree;

螺内酯;急性心肌梗死;心功能;P波离散度;

69. Keywords spironolactone;insulin resistance;hypertention;

螺内酯;胰岛素抵抗;高血压;

70. Keywords spironolactone;hypertension;cardio protection;

螺内酯;高血压;心脏保护;

71. Spironolactone has a direct portal hypotensive effect in addition to its ability to reduce plasma volume by diuresis.

螺内酯具有直接降低门静脉压力的作用，同时它也能通过利尿作用降低血浆容量。

72. Effects of combination of spironolactone and losartan on myocardial healing during the early stage of acute myocardial infarction in rats

螺内酯和氯沙坦及二者合用对大鼠急性心肌梗死早期愈合的影响

73. An experimental study of the preventive effects of spironolactone on hepatic fibrosis

螺内酯在预防大鼠肝纤维化形成中的作用

74. The effect of spironolactone on some neurohormonal factors in patients suffering cardiac insufficiency secon-dary to dilated cardiomyopathy

螺内酯对扩张型心肌病心力衰竭患者某些体液因子的影响

75. Preventive and therapeutic effects of spironolactone on renal tubulointerstitial fibrosis after unilateral ureteral obstruction in rats

螺内酯对梗阻性肾病大鼠肾间质纤维化的防治作用

76. Effects of spironolactone on myocardial fibrosis and left ventricular function in old patients with mild heart failure

螺内酯对老年人轻度心力衰竭心肌纤维化和心功能的影响

77. Spironolactone has a direct effect on the vasculature and suppressive effect on immunoactive and inflammatory cytokines, independent of its anti-aldosterone effect.

螺内酯对血管系统有直接作用并能直接抑制免疫活性和炎症因子，而不依赖其抗醛固酮作用。

78. Spironolactone ameliorates renal tubulointerstitial fibrosis of rat unilateral ureteral obstruction model

螺内酯抑制大鼠单侧输尿管梗阻后肾间质纤维化

79. The mechanism of spironolactone against calcineurin-dependent cardiac hypertrophy in renal hypertension rats

螺内酯抗钙调神经磷酸酶依赖的肾性高血压大鼠心肌肥厚作用机制

80. Spironolactone measurement

螺内酯测量