telomere

telomere

1. Alteration and significance of telomere length of peripheral white blood cells in patients with type 1 diabetes mellitus

1型糖尿病患者外周血白细胞端粒长度的变化及其意义

2. 5 Maruyama Y, Hanai H, Fujita M, Kaneko E. Telomere length and telomerase activity in carcinogenesis of the stomach.

4徐萍，唐永明，卜小兵，黄重发.胃癌组织中端粒酶活性研究.中华消化内镜杂志，1999；16：170

3. No association was observed between TRF length and MSI or frameshift mutation. But LOH at the DCC locus were associated with telomere shortening ( P <0.01).

DCC基因LOH与TRF缩短有关 ,APC和MCC基因亦有随TRF缩短而LOH率增高的倾向。

4. DNA demethylation leads to telomere shortening with accelerated aging process in human diploid fibroblasts

DNA去甲基化引起人二倍体成纤维细胞端区缩短并加速衰老进程

5. Keywords DNA double strand breaks;non-homologous end joining;DNA-dependent protein kinase;telomere;viral integration;

DNA双链断裂;非同源末端连接;DNA依赖蛋白激酶;端粒;病毒整合;

6. Keywords Immortal DNA strands;Aneuploidy;Gene mutation;Tumor stem cells;Adult stem cells;label-retaining cells;Cell clonality;Telomere;

DNA永生化链;非整倍体;基因突变;肿瘤干细胞;成体干细胞;标记滞留细胞;细胞克隆形成能力;端粒;

7. The Telomere Tructure in DNA and Its Replication

DNA的端粒及其复制

8. The POT1 (protection of telomeres) protein binds the singlestranded overhang and is required for both chromosomal end protection and telomere length regulation.

POT1蛋白与单链的突出端结合并被认为是保护染色体末端和调节端粒长度所必需的。

9. telomere repeat amplification protocol

TRAP

10. telomere or terminal banding(chromosome)

T带或粒带(染色体)

11. "Such a relationship between leukocyte telomere length and physical activity remained significant after adjustment for body-mass index, smoking, socioeconomic status and physical activity at work," the authors wrote.

“在对身体质量指数、吸烟、社会经济状况以及工作时的身体活动等因素进行调整后，白血球端粒和身体活动之间的这种关系依然明显，”这位作者写道。

12. A Simple and Highly Efficient Method for Cloning Telomere Associated Sequences from Oryza sativa

一种简单高效的克隆水稻端粒相关序列的方法

13. ethylene telomer

乙烯调聚物

14. Correlations of Telomere Length and Telomerase Activity to Radiosensitivity of Human Laryngeal Squamous Carcinoma Cells

人喉鳞癌细胞端粒长度、端粒酶活性与放射敏感性的关系

15. The quantificational relationship between the length of telomere DNA and age in peripheral blood leukocytes

人外周血白细胞端粒DNA长度与年龄的定量关系

16. Expression of hPOT1 is Associated with Tumor Grade and Telomere Length in Glioma

人端粒保护蛋白（hPOT1）在胶质瘤中的表达与肿瘤分级和端粒长度之间的相关性研究

17. Keywords hTERT;RNAi;proliferation;replicative senescence;apoptosis;TRAIL;telomere;telomerase;apoptosis-associated protein;gastric carcinoma;hepatocellular carcinoma;colon carcinoma;

人端粒酶逆转录酶;RNA干扰;增殖;衰老;凋亡;TRAIL;端粒;端粒酶;凋亡相关蛋白;胃癌;肝癌;结肠癌;

18. The telomere reserve of neonatal stem cells suffices for about a decade, judging from the age of onset of dyskeratosis congenita a disease associated with inadequate telomere maintenance.

从先天性角化不良症（一种端粒维护不当的相关疾病）发作年龄来判断,新生儿的干细胞端粒储备足够满足约10年。

19. His work showed that the inability to add nucleotide repeats to chromosomes led to telomere shortening and eventually cell death.

他的研究表明向染色体中添加核苷酸重复并不会导致端粒减短及最终的细胞死亡。

20. But telomeres have been attracting attention from researchers. Telomere length has been linked to life span. Longer telomeres have been associated with longer lives and vice versa.

但染色体端粒已经引起了研究者的关注,端粒长短与寿命长短又关联,长端粒已经被证实和长寿有关,反之亦然。

21. DNA Health Telomere Control Plan

健康端粒调控计划

22. Dynamical equation of chromosome telomere in cellular automata

元胞自动机中染色体端粒的动力学方程

23. Key investigators: In each of the relevant areas there are several groups with the necessary expertise, and most of them are already focused on the relevance of telomere maintenance to cancer.

关键的研究人员：在每一个相关领域中有几个具有专门技术的课题组，它们大部分已经关注到端粒维持与癌症的相关性。

24. Keywords head and neck squamous cell carcinoma （HNSCC）;chromosome;karyotype;centrosome;telomere;breakage-fusion-bridge cycle;

关键词头颈部鳞状细胞癌;染色体;核型;中心体;端粒;断裂-融合-桥周期;

25. Keywords leukemia/drug therapy;harringtonines/pharm acology;telomere;

关键词白血病/药物疗法;三尖杉酯碱类/药理学;端粒;

26. Keywords Telomere;G-quadruplex;Curcumin;Daidzin;CD;ESI-MS;

关键词端粒;G-四链体;姜黄素;黄豆苷;圆二色谱;电喷雾质谱;

27. Keywords telomere;short-hairpin RNA interference;DNA;damage response;

关键词端粒;短发夹RNA;DNA;损伤反应;

28. Keywords gastrointestina tract neoplasm;telomere;terminal transferase;enzyme|linked immunosorbent assay;

关键词胃肠肿瘤;端粒;末端转移酶;酶联免疫吸附试验;

29. Keywords Senescence Telomere Cell signal transduction Cell apoptosis Caveolae;

关键词衰老;端粒;细胞信号转导;细胞凋亡;小窝;

30. Keywords esophageal carcinoma;telomerase;Telomere repeat amplifieation protocal-random Millipore mating;

关键词食管癌;端粒酶;端粒酶重复扩增-微孔板杂交;

31. One of chromosome telomere behavior and abnormal expression of telomerase play an important role in tumor formation.

其中染色体端粒行为及端粒酶表达异常在肿瘤形成中扮演重要角色。

32. The study of telomere length in peripheral white blood cells of patients with coronary atherosclerosis and its significance.

冠状动脉粥样硬化患者外周血白细胞端粒长度研究及意义。

33. Untucked, a single-stranded telomere end is vulnerable to fusion with other single-stranded ends.

单股的端粒末端一旦展了开来，就很容易与其他的单股端结合；

34. The discovery of the telomere that portion of human DNA that controls life span in cells is one such development.

发现DNA的端粒来控制细胞寿命，就是这样的一个很大的进步。

35. Sure enough, the data indicated that higher levels of circulating vitamin D was associated with longer telomere length.

可以肯定的是，研究数据表明生理循环中更高水平的维生素D和较长的端粒有关。

36. Ethene, tetrafluoro-, telomer with pentafluoroiodoethane;

名称 四氟乙烯、五氟一碘乙烷调聚物;

37. Telomere and telomerase reprogramming in early mammalian embryo development

哺乳动物早期胚胎端粒和端粒酶重编程

38. G-quadruplex is a special structure formed by telomere.

四联体是端粒形成的一种特殊的结构。

39. A single fountain-of-youth elixir is highly unlikely,says Tamara Harris of the National Institute on Aging,because other activities,such as free-radical oxidation and possibly telomere shortening,also contribute to the body's slow decline.

国家老年研究所的塔玛拉·哈里斯说，不可能仅仅有一种永驻青春的不老药，因为其它活动如自由基氧化作用和缩短调聚作用放慢身体退化的过程。

40. Overexpression of MKRN1 in telomerase-positive cells promotes the degradation of hTERT and decreases telomerase activity and subsequently telomere length.

在实验中，MKRN1蛋白能将肿瘤细胞中的端粒酶清除掉。令人惊奇的是MKRN1基因非常古老。

41. We summarize the present research of telomerase and telomere and their applications on ocular disease.

在此,我们就端粒、端粒酶研究现状及其与眼科疾病的关系和应用进展作一综述。

42. Why is this important" In embryonic cells (and some stem cells), an enzyme called telomerase rebuilds the telomere so that the cells can keep dividing.

在胚胎细胞（还有一些干细胞），一种叫做端粒末端转移酶的酶可以重建端粒，以便细胞能保持分裂。

43. In gene therapy, gene transfer is targeted into specific tumor tissue by using relatively specific markers in brain gliomas such as EGFR, telomere and telomerase.

在胶质瘤的基因治疗中,利用脑胶质瘤组织中相对特异性的标志物如表皮生长因子受体、端粒及端粒酶等实现目的基因在肿瘤组织的靶向性表达;

44. A Digoxin-Labelled Method to Measure the Length of Telomere Restriction fragment of Human Chromosome

地高辛标记法检测人源细胞系端粒长度

45. The mechanism is not clear, maybe relate to bystander effect, free radicles, DNA repair-deficiency, telomere function disorder and gene partial or total deletion.

基因组不稳定性的机制目前还不甚清楚,可能与旁效应、自由基、DNA修复缺陷、端粒功能失调以及基因大片段缺失等有关。

46. Keywords Multicolor FISH; Telomere and centromere probes; Translocation; Previous radiation exposure; Dose reconstruction;

多色荧光原位杂交;端粒和着丝粒探针;易位;早先受辐射照射;剂量重建;

47. Telomere length and DCC gene mRNA expression of human large intestine cancers

大肠癌中端粒长度与DCC基因mRNA表达的研究

48. Keywords colorectal neoplasms;telomere;gene expression;

大肠肿瘤;端粒;基因表达;

49. Expression and length of telomere of cardiomyocytes after myocardial infarction in rat

大鼠心肌梗死后心肌细胞端粒酶表达水平及端粒长度变化的实验研究

50. The results of the higher serum vitamin D concentrations are associated with longer leukocyte telomer length in women.

妇女血清高维生素D浓度的这一结论与白细胞调聚物的长度较长有关。

51. Their DNA is circular and is not complexed with proteins. it lacks the centromere, telomere, and other structures of the eukaryote chromosome.

它们的DNA是环状的，没有蛋白质结合的。缺少着丝粒，端粒，以及一些其他真核生物染色体具备的结构。

52. It would have telomere DNA at the center, and it would have two centromeres.

它的中心部位将有端粒DNA，而且会同时含有两个着丝粒。

53. Measurement of telomere length of intercapillary cells by real - time quantitative PCR

定量聚合酶链反应对系膜细胞端粒长度的测定研究

54. Mapping genetic Loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs

对未选择的女性双卵双胞胎大样本的遗传基因位点作图决定白细胞端粒的长度

55. This paper made a summary of the recent researches on the structure and function of telomere and telomerase as well as the relation between telomerase and tumors.

对近年来端粒、端粒酶的结构与功能、端粒酶与肿瘤的关系进行了综述。

56. Measurement of telomere length of the patients of uremia

尿毒症患者染色体端粒长度改变的研究

57. Gilley D.Tanaka H.Hande MP.Kurimasa A,Li G C,Oshimura M,Chen DJ DNA-PKcs is critical for telomere capping 2001

张亮.张坚.周玉祥.程京DNA芯片技术中利用内标对数据归一化后检测基因的表达变化[期刊论文]-中国生物化学与分子生物学报2002(1

58. As the chondrocyte cells divide, they lose a bit of telomere length.Telomeres have been shown to dictate cell lifespan.

当细胞分裂时，他们会丧失少部分的染色体终端长度，染色体终端被证实是支配著细胞的寿命。

59. Unchecked telomere loss by HSC, meanwhile, would appear to play a significant role in the pathogenesis of bone marrow failure, as observed in the condition dyskeratosis congenita.

当观察到角化不良的现象时，端粒缺失可能在骨髓衰竭的发病中起关键作用。

60. Telomere length is regulated by telomere binding protein, telomere cap protein, DNA duplicase and telomerase.Telomerase plays the most important role in maintaining telomere length.

影响端粒长度的因素包括：端粒结合蛋白、端粒帽蛋白、端粒酶及DNA复制酶等，其中端粒酶是最主要的因素。

61. Overall, the study participants had an average telomere loss of 21 nucleotides (structural units) per year.

总的来说，该项研究的参与者每年平均损失21个核甘酸（结构单位）。

62. Thus we used MD tumor as research model and investigated the mechanism of MDV oncoginisis by researching telomere ,telomerase , tumor suppressors of chicken and MDV oncogene .

我们以MD肿瘤为模型，从端粒及端粒酶、肿瘤抑制因子、MDV的相关致瘤基因等的研究入手，对MDV的致瘤机理进行了研究。

63. Our findings support the idea that pathways leading to telomere shortening are inoled in the pathogenesis of this disease.

我们的研究结果支持这样的设想，即导致端粒变短的机制与家庭性特发性肺纤维变性的发生有关。

64. Abstract： Objective: To investigate the relationship of expression level of telomere binding factor with the degree of malignancy of hunan gliomas.

摘 要： 目的：探讨细胞端粒结合因子的表达水平与肿瘤细胞恶性程度的关系。

65. Abstract Purpose : To establish a nonradio - labelled method for measuring telomere length (mean length of telomere rest riction f ragment , TRF) of human chromosome.

摘要 目的:建立一种非同位素标记测定端粒长度的方法。

66. Telomere is at the end of the chromosome in eukaryotic cells and protects chromosomes.

摘要端粒位于真核细胞染色体末端，起保护染色体末端的作用。

67. Telomere is an important DNA-protein structure.It caps the ends of linear eukaryotic chromosomes.Telomeric DNA consists of tandemly repeated simple sequences.

摘要端粒是构成真核生物线状染色体末端重要的DNA-蛋白质复合结构，DNA由简单的串联重复序列组成。

68. Keywords Radioresistant cell line;Radiosensitivity;Telomerase;Telomere;Telomerase inhibitor;

放射抗拒细胞株;放射敏感性;端粒酶;端粒;端粒酶抑制剂;

69. The new fragment identifies an ELC, located close to a telomere.

新片断确定了靠近端粒的ELC。

70. Keywords olvent free epoxy adhesive Toughness Filler Telomer Polymer Powder Additive;

无溶剂环氧胶粘剂;韧性;填料;低聚物;聚合物粉末;填加剂;

71. telomere transcriptase

末端转移酶

72. This paper is a review of telomere, telomerase, telomere-binding protein and developmental control of telomere change, telomerase activity in higher plant.

本文就植物端粒、端粒酶、端粒结合蛋白，以及端粒变化、端粒酶在植物生长发育中的调节作一概述。

73. The three strategies to construct HAC have been explored without full knowledge of chromosome elements such as centromere,telomere and replication origin.

本文探讨了在不完全了解着丝粒、复制起始点、端粒等人类染色体基本功能单位的情况下构建HAC的三种策略。

74. The experiment detected the telomerase activity of oocytes, 4-cell, 8-cell, morula and blastocysts in Boer goat embryos by Telomere Repeat Amplication protocol(TRAP).

本试验利用端粒重复序列扩增法(TRAP)测定了波尔山羊卵母细胞、4-细胞、8-细胞、桑椹胚和囊胚胚胎的端粒酶活性。

75. chromosome telomere

染色体端粒

76. Moreover, it was not merely the father's telomere length that correlated with that of his offspring, but also his actual lifespan.

此外，不仅仅是父亲的端粒长度与其子孙后代的端粒长度相关，而且他们与孩子之间的寿命也相关。

77. In addition, estimating age of humans based on telomere shortening will display enormous applicational prospect in forensic medicine.

此外，利用端粒长度变化与年龄的相关性评估人的年龄将在法医学界显示其巨大的应用前景。

78. Moreover, differences in telomerase expression, telomere length and cell kinetics between normal and tumour tissues suggest that targeting telomerase would be relatively safe.

此外，正常细胞和肿瘤组织之间的端粒酶表达，端粒长度和细胞动力学的差异提示：靶向端粒酶相对比较安全。

79. The activity of the GSH-PX and telomere length were determined in the liver.

测定肝组织中谷胱甘肽过氧化物酶(GSH-PX)活性和肝细胞端粒长度。

80. Effect of Flanking Sequence on the Thermal Stability and Folding Kinetics of Telomere G-Quadruplex

热稳定性和折叠与去折叠动力学的影响