ugt

ugt

1. The results of analysis by MGT cover those by UGT.

两研究相比较，体现了多元概化分析较之单变量概化分析的优越性所在。

2. Key Words：UDP-glucuronosyltransferase（UGT）；polymorphism；benzidine；Papanicolaou gradings（PG）

关键词：葡萄糖醛酸转移酶；多态性；联苯胺；巴氏分级

3. uridine diphosphate glucosyl/glucuronosyhransferase (UGT)

尿苷二磷酸葡萄糖醛酸转移酶

4. AIM To screen or validate the substrates of uridine 5'-diphosphate glucuronosyltransferases (UGT) 1A6 with a recombinant human UGT1A6 expressed by baculovirus expression system.

摘要目的利用杆状病毒系统表达的人尿苷二磷酸葡醛酸转移酶(UGT)1A6重组酶对一些化合物进行葡醛酸结合研究，以筛选或验证UGT1A6重组酶的底物。

5. METHOD:Reading a lot of related materials and summarizing the UGT functions?induction?substrates and its genes research;

方法:查阅了大量相关文献,总结了UGT的功能、诱导、底物及其基因研究等内容;

6. Because of the importance of UGTs in drug metabolism in humans, the identifications of key UGT enzymes are very important.

由于UGT酶在人类药物代谢方面的重要性,对关键UGT酶的鉴定是十分重要的,需要引起人们日益的重视。

7. At present, about 15 human UGT have been identified, and muc h more knowledge about substrate selectivity of UGT has been reported. However, the study on enzymology of UGT lags behind that of cytochrome P450.

目前 ,有 15种人类UGT被确证有活性 ,而且对它们的底物选择性方面有了进一步认识 ,但UGT的酶学研究相对于细胞色素P4 5 0还比较落后 ,有待于进一步提高。

8. OBJECTIVE:To intraduce the advance in the research of UDP-glucuronosyltransferase(UGT) in recent years;

目的 :介绍尿苷二磷酸葡萄糖醛酸转移酶 (UGT)的最近研究进展 ;

9. Objective: To investigate the influence of hepatitis and cirrhosis on hepatic UGT isoforms expression.

目的:探讨肝炎和肝硬化疾病对尿苷二磷酸葡萄糖醛酸基转移酶(UGT)表达水平的影响。

10. CONCLUSION:people can understand UGT more deeply and widely than before.

结论:人们对UGT有了更深更全面的了解。

11. Liver is the main organ for drug metabolism, it nearly have all UGT isozymes.

肝脏是葡醛酸缀合反应的主要场所，几乎含有所有的UGT同工酶。

12. UDP-glucuronosyltransferase( UGT)

葡萄糖醛酸转移酶

13. Keywords UDP-glucumnosyltransferase（UGT）;polymorphism;benzidine;Papanicolaou gradings（PG）;

葡萄糖醛酸转移酶;多态性;联苯胺;巴氏分级;